氨基酸系列水杨醛希夫碱与四苯基卟啉结合金属离子能力之比较

Comparison of Metal-binding Capabilities between Amino Acid-Salicyadehyde Schiff Base and Tetraphenylporphyrin

合成了甘氨酸(Gly-Schiff base)、L-苯丙氨酸(L-Phe-Schiff base)及L-天冬氨酸(L-Asp-Schiff base)3种氨基酸水杨醛希夫碱(AAS)及其4种金属离子Cu2+、Fe2+、Ni2+、Zn2+配合物(MAAS),将四苯基卟啉(TPP)直接加入MAAS的氯仿溶液中,研究其紫外-可见电子吸收光谱.分析了卟啉作为信号转导体系中信号传递中间介质,实现人工细胞信号转导体系中信号传递的可能性.表明Cu2+、Ni2+能够在常温常压下被卟啉从希夫碱上夺取下来,形成金属卟啉配合物.这说明在文中所构建的人工细胞信号转导体系中,加入卟啉分子可以将信号分子Cu2+进行下一步的传递.

Three amino acid- salicyadehyde schiff bases（AAS） and their complexes with four metallic ions Cu^2＋ , Fe^2＋ , Ni^2＋ , Zn^2＋ were synthesized, such as Gly - salicyadehyde schiff- base, L- Asp - salicyadehyde schiff- base, L- Phe - salicyadehyde schiff- base. Tetraphenylporphyrin was added into the MAAS chloroform solution. The UV - vis spectra were then investigated. The possibility of porphyrin used as the transitive medium in the synthetic signal transduction system to achive the transduction was discussed. The result showed that Cu^2＋ ,Ni^2＋ could be replaced from MAAS to the porphyrin, and the metal porphyrin was received. It illuminated that the signal Cu^2＋ can carry out the next transfer by adding porphyrin.