中西医结合治疗急性脑梗塞的疗效和其对促肾上腺激素及超氧化物歧化酶的影响

Therapeutic effects of integrated traditional Chinese and western medicine on acute cerebral infarction and changes of adrenocorticotropic hormone and superoxide dismutase levels

目的：探讨中西医结合治疗急性脑梗塞的疗效和其对促肾上腺激素（ＡＣＴＨ）和超氧化物歧化酶（ＳＯＤ）的影响。方法：对４５例急性脑梗塞患者行中西医结合〔紫外线照射充氧自血回输（ＵＢＩＯ）＋高压氧（ＨＢＯ）＋活血化瘀补肾中药〕治疗；３０例用ＵＢＩＯ＋ＨＢＯ治疗；３５例患者用复方丹参治疗作对照组。结果：中西医结合治疗急性脑梗塞治愈率及总有效率分别为４０．０％及９５．６％，复方丹参对照组分别为１４．３％及７１．４％，ＵＢＩＯ＋ＨＢＯ组分别为３３．３％和９０．０％。中西医结合治疗后ＡＣＴＨ及ＳＯＤ水平明显增高，与对照组比较差异有显著性，ＡＣＴＨ及ＳＯＤ变化趋势呈一致性。结论：中西医结合治疗使内分泌系统的垂体下丘脑肾上腺轴激素分泌作用增强，内环境ＳＯＤ对自由基清除力增高，疗效高。

Objective:To research the therapeutic effects with integrated traditional Chinese and western medicine on acute cerebral infarction (ACI) and changes of adrenocorticotropic hormone(ACTH) and superoxide dismutase(SOD) level.Methods:45 cases with ACI were treated with integrated traditional Chinese and western medicine;30 cases were treated with ultraviolet blood irradiation O 2(UBIO)+hyperbaric oxygen(HBO);35 cases were treated with composite “dan shen” injection as control group. Results:Therapentic and total effective rates were 40 00% and 95 60% respectively in therapy group;14 30% and 71 40% respectively in control group;33 30% and 90 00% respectively in UBIO+HBO group.ACTH and SOD levels in the therapy group were significantly higher than those in control group.The changes of ACTH and SOD were correspondence.Conclusions:The integrated treatment can increase secretion of endocrine hormone in HPA axis and increased the clearing velocity of free radical.