小儿脑性瘫痪高危因素的调查与分析

Investigation and analysis on high risk factors of infantile cerebral palsy

目的探讨脑性瘫痪患儿的高危因素。方法采用回顾性调查分析4706例脑瘫患儿产前母体因素、产时及新生期危险因素。同时选择等量在我院儿童保健科进行儿童保健的正常同龄儿童作为对照。计数资料采用频数分布及百分构成比进行描述;危险因素的分析采用1:1匹配单因素条件Logistic回归分析,并进行1:1匹配多因素条件Logistic回归分析来控制混杂因素对结果的影响。结果60·4%有产前母体因素,24·5%为出生时异常因素,14·5%的患儿曾有新生儿期异常因素,0·3%有遗传因素,0·3%无明显原因。结论产前母体因素是造成脑瘫的主要原因,也是造成产时及某些新生儿期因素的重要原因,应加强孕期保健,重视孕期孕母相关的环境、营养、保持良好的心态,以降低脑瘫儿的发病率,提高患儿生存质量。

Objective To investigate the high degree of risk factors in children＇s cerebral palsy （CCP）. Methods We retrospectively investigated and analyzed the risk factors with 4706 cases of CCP in pregnancy, parental and neonatal period. In contrast, we also selected 4706 cases of normal children in the same age that came here to make health care. The dates would be described by fre- quency and percentage methods . The Logistic review method will be used to analyze the risk factors in 1 ： 1 ration single factor condi- tion, to control the mingle factors＇ effect in 1 ： 1 ration most factors condition. Results About 60. 4% of them had abnormal factors in pregnancy,24. 5% of them in prenatal period and 14. 5% in neonatal period. In addition,about 0. 3% of them had hereditary factors, but there were about 0.3% of them with non-factors. Conclusion The factors of mother are the primary cause not only of CP, but also of some diseases in labor or notation period. In order to reduce the incidence of CCP and promote their live, we must provide mothers in pregnancy with well circumstance and well-nourished, and make them kept good minds.