川芎提取物对神经刺激所致猪脑动脉反应的影响

The effect of extract of Ligusticum chuanxiong Hort on the responseto nerve stimulation in pig cerebral arteries

目的观察川芎提取物对神经刺激引起的猪脑动脉反应的作用及其与一氧化氮的关系。方法采用离体去除内皮血管方法,测定脑动脉条的等容张力变化及药物的作用。结果川芎提取物对电刺激或化学刺激引起的血管舒张反应具有增强作用,此作用不受酚妥拉明和哌唑嗪、心得安、阿托品、消炎痛的影响,但可被一氧化氮合酶抑制剂L-硝基精氨酸抑制,该抑制作用又可为一氧化氮供体L-精氨酸逆转。结论川芎提取物对电刺激或化学刺激所致血管舒张反应的增强作用可能与一氧化氮有关。

Objective To observe the effects of extract of Ligustieum ehuanxiong Hort on the response to nerve stimulation in pig cerebral arteries and their correlation with nitric oxide（NO） .Methods The isometric tension of endothelium-denuded isolated cerebral artery strips from pigs wasmeasured by a foreedisplaement transducer. Results In the endothelium denuded isolated eerdbral artery strips treated with pmxosin, electrical stimulation and nicotine produced a relaxation, which were potentiated by extraet of Ligustieum ehuanxiong Hort. These effects were not altered by phentolamine, proranolol, atropine and indomethaein, however, which were inhibited by N^G-nitrio-L-arginine （L- NA）, NO synthesis inhibitor. L-arginine reversed the inhibition of L-NA. Conclusion The extract of Ligustieum ehua nxiong Hort can potentiate the relaxation induced by electrical stimulation and nicotine, which may be related with NO.