癫痫患者脑脊液生长抑素测定

Somatostatin Assay by RIA in Cerebral Spinal Fluid of Epileptic Patients

本文对25例正常人37例癫痫（EP）患者脑脊液做生长抑素（SOM）测定，发现正常人≤20岁与＞20岁SOM差别有显著意义，即年龄越大，脑脊液中（CSF）SOM值越低。在癫痫组，年龄＞20岁CSF中SOM水平显著高于对照组（P＜0．01）。发作形式对CSF-SOM无影响。发病年限≤10年，SOM值明显高于对照组（P＜0．05），发病＞10年的，SOM值与对照组无差异。同时发现长期用抗癫痫药者，CSF-SOM值与对照组无差异，未用药者明显高于对照组（P＜0．001）。CSF1-SOM的变化与CT，MRI的改变及SPECT所示放射性同位素吸收稀疏区相关。

In the present study, the somatostatin (SOM) concentrations in CSF of25 control subjects and 37 epileptic patients were measured by I radioimmunoassay (RIA )method. In control group, SOM levels was obviously different betweem ＜20 years and ＞ 21 years (P＜0. 05). In Ep group, SOM was higher than control group in ＞21 years old (P＜0. 01 ). CSFSOM levels was higher in patients with epileptic histrol＜10 years and no in take antiepileptic medicine than control (P,0. 05) (P＜0. 001).