天门冬氨酸转氨酶同工酶测定对心、肝疾病诊断的临床意义

Clinical ralue of mitochondrial aspartate aminotransferase in diagnosing cardiac and hepatic diceases

目的通过对心、肝疾病患者血清线粒体天门冬氨酸转氨酶(mitochondrial aspartate aminotransferase,m-AST)的测定,探讨其在心、肝疾病诊断中的价值。方法采用免疫抑制法测定56例心脏疾病和118例肝脏疾病患者血清m-AST活性。结果心肌病组m-AST水平显著高于正常对照组,差异有统计学意义(P<0.01),心肌梗死组差别最显著;肝脏疾病组与正常对照组比较,急性肝炎、慢性中度、重度肝炎m-AST显著高于对照组,差异有统计学意义(P<0.01);而肝硬化、原发性肝癌患者中仅有轻度增高。结论血清m-AST的测定是心、肝疾病良好的辅助诊断指标之一。

Objective To study the clinical value of mitochondrial aspartate aminotransferase（m-AST）in cardiac and hepatic diseases. Methods The serum m-AST activity in 56 heart disease patients and 118 liver disease patients were measured by immunity inhibition methods. Results The m-AST activity of myocardiosis patients was significantly higher than that of the normal control group（P〈0.01）. Most significant difference was found in myocardial infarction group. The m-AST activity of acute hepatitis, nroderate and severe chronic hepatitis patients was also significantly higher than that of the normal control group（P〈0.01）but only increased slightly in cirrhosis and liver cancer patients. Conclusion The serum m-AST activity is a good assistant diagnosis index to heart and liver diseases.