摘要
目的探讨淫羊藿苷对异丙肾上腺素(ISO)致大鼠急性心肌缺血的作用。方法淫羊藿苷(12、6、3mg·kg-1)静脉注射给药5d,采用ISO(30mg·kg-1,每日1次,连续2d)sc诱导大鼠急性心肌缺血模型,观察大鼠心电图的变化,测定血清中乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)的含量,测定心脏指数(HW/BW和LVW/BW)和心肌梗死面积(IS/V%)。结果和模型组相比,淫羊藿苷(12、6、3mg·kg-1)均能有效对抗心电图T波和J点的变化,降低血清中LDH、SOD、MDA和NO的含量(P<0.01或P<0.05),降低心脏指数(P<0.01或P<0.05)和心肌梗死面积(P<0.01)。结论淫羊藿苷对ISO所致大鼠急性心肌缺血有一定的保护作用。
Aim To investigate effects of Icariin in rats with acute myocardial ischemia induced by isoproterenol（ISO）. Methods Icariin（ 12,6,3mg · kg^-1 ） was administrated through iv pathway for five days. Myocardial ischemia model of rats was induced by subcutaneous injection（sc） of ISO（30mg · kg^-1 for two days, once a day）. The change of Electrocardiogram （ECG） was observed. The levels of lactate dehydrogenase （ LDH ） , superoxide dismutase （ SOD ） , malondialdehyde （ MDA ） and nitric oxide （ NO ） in serum were measured. Cardiac indexes （HW/BW and LVW/BW） and cardiac infarction area （ IS/V% ） were examined.Results Compared with the model group, Icariin （ 12, 6,3 mg · kg^-1） could effectively reverse the evident change of T wave and J point induced by isoproterenol, notably decrease the levels of LDH and MDA in the serum, distinctly increase the levels of SOD and NO in the serum（P 〈0. 01 or P 〈0. 05） ,and significantly reduce the cardiac indexes（P 〈0. 01 or P 〈0. 05） and cardiac infarction area（P 〈0. O1 ）. Conclusion Icariin has a protective effect against ISO-induced acute myocardial isehemia in rats.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2007年第5期622-625,共4页
Chinese Pharmacological Bulletin
基金
国家"九五"重点科技攻关资助项目(No99-929-01-31)
