交感神经对血管源性头痛痛觉传导通路的影响

Involvement of Sympathetic Nerve System in Vascular Headache

目的探讨交感神经系统在血管源性头痛伤害性信息传递中的作用。方法雄性SD大鼠行颈上交感神经节(SCG)摘除术后再手术暴露其上矢状窦(SSS),电刺激SSS区硬脑膜,应用免疫组织化学染色技术,观察中脑导水管周围灰质(PAG)区域Fos蛋白表达的变化。结果Fos免疫反应阳性神经元主要分布在PAG的腹外侧区,双侧对称。实验组Fos阳性神经元数目较假手术组增加(P<0.05)。结论颈交感神经系统通过PAG对痛觉的中枢调整参与了血管源性头痛中伤害性感觉信息的产生、传导及调节过程。

Objective To investigate the involvement of sympathetic nerve system in the transmission of nociceptive information related to vascular headache. Methods Fos expression in the midbrain periaqueductal grey （PAG） induced by electrical stimulation of dural matter near the superior sagittal sinus （SSS） of the rat was determined before and after the extirpation of the superior cervical ganglion （SCG） using standard avidin-biotin immunohistochemistry. Results Fos immunoreactive positive neurons were detected in the ventrolateral PAG, and were bilateral symmetry. Fos expression was （133.3±12.5） in SCG extirpated group, and higher than that in sham-operated group （76.0±11.3）. Conclusion The sympathetic system may be involved in the transmission of nociceptive information through PAG, associated with vascular headache such as migraine.