HSP70蛋白在胃癌中的表达

Expression of Heat Shock Proteins in Gastric Carcinoma

目的探讨热休克蛋白(heat shock proteins,HSPs)在人胃癌组织中的表达。方法采用EnVision免疫组化分别检测HSP70在正常胃黏膜、不典型增生、胃癌组织中表达。结果HSP70在正常胃黏膜、不典型增生、胃癌组织中的阳性率分别为58%、66%、72%,过表达率分别为8%、31%、57%。在胃癌组织和不典型增生胃黏膜中HSP70的表达明显高于正常胃黏膜中的表达(χ2=12.16,P<0.05)。结论HSP70在胃癌和不典型增生病变中呈现过度表达,可应于早期诊断和评估胃癌的发生,进一步研究其分子机制将为胃癌的治疗提供理论依据。

Objective To determine the expression of HSP70 in gastric carcinoma and normal gastric epithelia. Methods Immunohistochemical technique, Envision method was used to examine the expression of HSP70 protein in gastric carcinoma, dysplasia and normal gastric mucosa. Results The expression of HSP70 protein was detected in 72 % of gastric carcinoma, 66 % of dysplasia, 58 % of normal tissue of gastric epithelia;Overexpression of HSP70 protein was found in 57% of gastric carcinoma, 31% of dysplasia, 8% of normal tissue of gastric epithelia. The expression of HSP70 protein in gastric carcinoma and dysplasia was higher than that in normal gastric epithelia（X^2 = 12.16, P 〈 0.05）. Conclusion The results that HSP70 protein were overexpressed in gastric carcinoma and dysplasia chould be used to evaluate earliar diagnosis and carcinogenesis of gastric tissue, further clarifying the mechanism of liSPs could help to provide theorical basis for the biological therapy of gastric cancer.