HLA-G分子在乳腺癌中的表达及意义

The Expression and Clinical Significance of HLA-G Molecule in Specimens in Breast Cancer

目的探讨乳腺癌患者组织中HLA-G的表达及其与临床病理指标的关系。方法用S-P免疫组织化学方法检测144例乳腺癌患者病理组织和20例乳腺良性肿瘤组织,比较HLA-G分子表达及其与临床病理指标之间的关系。结果(1)HLA-G分子在乳腺癌组织中表达率为39.5%(57/144),在乳腺良性肿瘤组织中表达率为0(0/20)。(2)HLA-G分子表达与乳腺癌临床TNM分期、组织学分级、腋窝淋巴结转移相关(P<0.05)。结论乳腺癌组织中HLA-G分子有较高表达,并且与肿瘤TNM分期,腋淋巴结转移,组织学分级显著相关。

Objective To investigate the expression of HLA- G and the relationship between HLA- G and clinicopathological Characteristics in breast cancer. Methods The expression of HLA - G of breast cancer specimens taken from 144 breast cancer patients and 20 benign breast tumour patients were examined by immunohistochemical S- P method. The expression of HLA- G was compared and the relation between HLA - G and clinicopathological characteristics in breast cancer was analyzed. Results （1）The positive expression rate of HLA - G was 39.5 % （ 57/144 ） in breast cancer and O （ 0/20 ） in benign tumour. （ 2 ） The expression of HLA - G was positively correlated with clinical TNM phase （ P 〈 0.05 ）, histological grade （ P 〈 0.05 ）, axilliary lymph nodes metastases （ P 〈 0.05 ）. Conclusions HLA - G highly expressed in breast Carcinomas, and was significantly associated with clinical TNM stage, histological grade and axilliary lymph nodes metastases.