期刊文献+

应用A型肉毒毒素治疗面肌痉挛 被引量:4

The clinical application of the treatment for the face muscle hyperkinesias with the Botulinum toxin type A
下载PDF
导出
摘要 目的:应用国产A型肉毒毒素治疗面肌痉挛55例并观察其远期疗效、并发症,提出治疗时的注意事项。方法:根据注射的肌肉大小决定注射点及每点的注射剂量,肌肉震颤最明显处。每注射点的肉毒毒素注射量约在15U左右,一次注射的总量一般控制在130U。首次注射后2周后复查,若痉挛未完全控制,可追加注射1次,方法相同,但注射量应减半。结果:55例患者首次注射后完全缓解38例,占69%,部分缓解17例,占31%,对部分缓解的患者10天后追加注射1次,疗效基本满意。所有患者均未出现全身及局部副作用。结论:该注射方法简单,安全无痛苦,毒副作用小,疗效佳,应当是目前治疗面肌痉挛较好的方法,尤其适合基层单位应用推广。 Objective To investigate the long-term effects and complications of the botulinum toxin type A used in 55 cases of the face muscle hyperkinesias in order to supply the key of the therapy. Methods The injection point and dosage are determined by the muscle mass. Gernally total dosage once should be controlled in 130u with 15u every injection point. Following up after 2 weeks, the patient was injected again with half dosage of the first time if the symptoms did not obtained completelyalleviated. Results 38 cases (69%) completely alleviated, 17cases (31%) partially alleviated without adverse effect. Addtionally injection to the latter also got good response. Conclusion The method is a simple and quite safe effective technology in treating the face muscle hyperkinesias. It shoud be used widely in basic units.
出处 《中国美容医学》 CAS 2007年第5期620-622,共3页 Chinese Journal of Aesthetic Medicine
关键词 肉毒毒素 面肌痉挛 注射 botulinum toxin face muscle hyperkinesias injection
  • 相关文献

参考文献6

  • 1王荫椿.肉毒毒素及其临床应用[J].卫生研究,1998,27(S1):10-14. 被引量:9
  • 2Lowe NJ,Yamauchi P.Cosmetic uses of botulinum toxins for lower aspects of the face and neck[J].Clin Dermatol,2004,22(1):3.
  • 3Carruthers A,Carruthers J.Botulinum toxin type A for the treatment of glabellar rhytides[J].Dermatol Clin,2004,22(2):137.
  • 4Foran PG,Mohammed N,Lisk GO,et al.Evaluation of the therapeutic usefulness of botulinum neurotoxin B,C1,E,and F compared with the long lasting type A.Basis for distinct durations of inhibition of exocytosis in central neurons[J].J Biol Chem,2003,278(2):1363.
  • 5Castro WH,Gomez RS,Da Silva Oj,et al.Botulinum toxin type A in the management of masseter muscle hypertrophy[J].J Oral Maxillofac Surg,2005,63(1):20.
  • 6朱力,王恒樑,黄留玉.肉毒毒素研究进展[J].生物技术通讯,2005,16(2):186-190. 被引量:32

二级参考文献48

  • 1Maksymowych AB, Simpson LL. Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells[J]. J Biol Chem, 1998,273(34):21950.
  • 2Shone CC, Hambleton P, Melling J. A 50-kDa fragment from the NH2-terminus of the heavy subunit of Clostridium botulinum type A neurotoxin forms channels in lipid vesicles[J]. Eur J Biochem, 1987,167(1):175.
  • 3Montal MS, Blewitt R, Tomich JM, et al. Identification of an ion channelforming motif in the primary structure of tetanus and botulinum neurotoxins [J]. FEBS Lett, 1992,313(1):12.
  • 4Schmid MF, Robinson JP, DasGupta BR. Direct visualization of botulinum neurotoxin-induced channels in phospholipid vesicles [J]. Nature, 1993,364(6440):827.
  • 5Sollner T, Bennett MK, Whiteheart SW, et al. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion[J]. Cell, 1993,75(3):409.
  • 6Martinez-Aroa S, Alberts P, Galli T. Clostridial neurotoxin-insensitive vesicular SNAREs in exocytosis and endocytosis[J]. Biol Cell, 2000,92(6):449.
  • 7Humeau Y, Doussau F, Grant NJ, et al. How botulinum and tetanus neurotoxins block neurotransmitter release[J]. Biochimie, 2000,82(5):427.
  • 8Hayashi T, McMahon H, Yamasaki S, et al. Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly [J]. EMBO J,1994,13(21):5051.
  • 9Hanson MA,Stevens RC. Cocrystal structure of synaptobrevin-R bound to botulinum neurotoxin type B at 2.0 A resolution[J]. Nat Struct Biol, 2000,7(8):687.
  • 10Ferrer-Montiel AV, Canaves JM, DasGupta BR, et al. Tyrosine phosphorylation modulates the activity of clostridial neurotoxins[J]. J Biol Chem, 1996,271(31):18322.

共引文献37

同被引文献37

  • 1于建敏,王艳,宋红平.A型肉毒毒素加强法治疗面肌痉挛[J].中国神经免疫学和神经病学杂志,2003,10(3):190-190. 被引量:9
  • 2张本恕,江德华.Meige综合征的临床及治疗[J].中华神经精神科杂志,1993,26(6):324-326. 被引量:9
  • 3黄秀君,公维志,东贵荣.Meige综合征临床误诊二例[J].中华神经医学杂志,2005,4(3):256-256. 被引量:6
  • 4朱力,王恒樑,黄留玉.肉毒毒素研究进展[J].生物技术通讯,2005,16(2):186-190. 被引量:32
  • 5袁继龙,王明利,柳大烈,袁强.A型肉毒毒素治疗鼻唇沟纹的临床应用[J].中国实用美容整形外科杂志,2005,16(4):229-230. 被引量:17
  • 6Schiavo G, Matteoli M, Montecucco C. Neurotoxins affecting neuroexocytosis. Physiol Rev, 2000, 80(2):717-720.
  • 7Foran PG, Mohammed N, Lisk GO, et al. Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A: Basis for distinct durations of inhibition of exocytosis in central neurons. J Biol Chem, 2003,278(2):1363 -1364.
  • 8Lowe N J, Yamauchi P. Cosmetic uses of botulinum toxins for lower aspects of the face and neck. Clin Dermatol, 2004, 22 (1): 3-6.
  • 9Castro WH, Gomez RS, Da Silva OJ, et al. Botulinum toxin type A in the management of masseter muscle hypertrophy. J Oral Maxillofac Surg, 2005,63(1) :20-21.
  • 10Fagien S. Botox for the treatment of dynamic and hyperkinetic facial lines and furrows: adjunctive use in facial aesthetic surgery. Plast Reconatr Surg, 1999,103(1) : 701-803.

引证文献4

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部