多发性硬化患者病情活动与血清尿酸水平变化的相关性研究

目的探讨多发性硬化(MS)患者病情活动与血清尿酸(UA)水平变化的关系。方法比较MS患者急性期及经大剂量甲泼尼龙(甲基强的松龙)冲击治疗后缓解期血清UA值,并与其他非炎症性神经系统疾病(non-inflammatory neurological disease,NIND)作对照,同时对比治疗前后头颅MRI增强检查情况及神经功能缺损评分。结果MS患者急性期血清UA水平显著低于缓解期及NIND组,缓解期血清UA值虽低于对照组,但差异无显著性。治疗前头颅MRI显示病灶明显强化,治疗后强化病灶显著减少,同时伴随着UA水平回升,神经功能缺损评分降低,临床症状改善。结论血清UA水平变化与MS患者病情活动密切相关,UA可作为观察MS病情活动性及激素疗效的指标之一,升高血清尿酸水平可能是一种有前途的治疗方法。

Objective To investigate the relationship of serum levels of uric acid （UA） and the activity of disease in multiple sclerosis （MS） patients. Methods Comparing the serum levels of UA in relapse with those in remission after high doses of intravenous methylpredrtisolone （IVMP） therapy in multiple sclerosis patients , and with those in non - inflammatory neurological diseases. Both the degree of neurologic impairment and the Gd2DTPA enhanced MRI lesions in the brains of MS were compared before and after IVMP treatment. Results The serum levels of UA in replase otMS were significantly lower than those in remission and control group. A decrease of the number of Gd2DTPA enhanced MRI lesions after IVMP treatment was accompanied with ascend of the serum levels of UA in RRMS patients. The clinical symptom and the neurologic impairment got better. Conclusions Low serum levels of UA are closely related to the attack of MS. The serum levels of UA help to judge the activity of MS and the theraputic effect of IVMP treatment. Rasing the level of the serum uric acid may be a anticipant therapy.