经肛巨结肠根治术后患儿的肛肠功能评价(英文)

Evaluation of anorectal function after transanal one-stage endorectal pull through operation in children with Hirschsprung′s disease

目的经肛门巨结肠一期根治术近期效果好，但术后患儿的肛肠功能目前尚不十分清楚。该文旨在评估患儿术后的排便模式，结肠和肛门括约肌功能。方法对58例经肛门巨结肠根治术后半年以上儿童进行随访，随访时间为15．8月（6～24月）。并进行排便功能问卷调查、钡灌肠、结肠传输时间和肛门直肠测压检查。33例正常儿童作为对照。结果大多数随访患儿排便正常，无任何临床症状。4例出现稀便便频，9例污便，5例便秘，3例小肠结肠炎。钡灌肠结果显示大多数随访患儿结肠形态恢复良好。全部病例术后直肠肛管角（度）较对照组显著开大，有症状组较无症状组显著开大。58例随访患儿的平均全胃肠、左半结肠和右半结肠传输时间较术前显著缩短，与对照组相比差异无显著性意义。直肠肛管反射5例阳性。便秘组的肛管最大静息压和最大收缩压明显高于无症状组和对照组。污便组向量容积和对称指数较对照组显著降低。便秘组对称指数显著高于对照组。结论经肛门巨结肠根治术后大多数患儿排便功能、结肠功能和括约肌功能良好。少数病例排便功能障碍可能与术后乙状结肠曲减少或消失、“新直肠”储便功能代偿不全和拖出结肠致直肠肛管角开大、肛门括约肌痉挛失弛缓有关。

Objective The short-term efficacy of the transanal one-stage endorectal pull through operation for Hirschsprung＇s disease is satisfactory. However the long-term outcome of anorectal function has not been fully understood. The aim of this study was to evaluate the stooling pattern, colonic motility and anal sphincter performance after transanal one-stage pull through operation in children with Hirschsprung＇s disease. Methods Fifty-eight children who underwent transanal one-stage pull through operation for Hirschsprung＇s disease were followed up. The mean follow-up duration was 15.8 months （range, 6-24 months）. The stooling patterns of the patients were investigated by the informed questionnaire. Barium enema, defecography, total and segmental colonic transit time and the anorectal vector manometry were performed. Thirty-three healthy children were used as controls. Results Most of patients had normal stool consistency and frequency. Postoperative enterocolitis occurred in 3 patients, and constipation was found in five patients. Postoperative soiling was observed in 9 patients. None of the 58 patients had incontinence, cuff infection, anastomotic leak and mortality. The barium enema showed that the configuration of the colon recovered well in most of patients. Postopertive defecography showed the anorectal angle of all the patients was open, fixed and bigger than that of preoperation and the healthy controls .（P 〈0.01 ）. Postoperatively, the mean total gastrointestinal transit time（ TGITF）, the left colonic transit time （LCTF） and rectosigmoid colonic transit time （RSTF） in the 58 patients were significantly shorter than preoperatively （P 〈 0.01 ） and were similar to those of the control group. The rectoanal inhibitory reflex was regained in 5 patients. The anal maximal pressure of the patients with constipation in resting and squeezing condition were significantly higher than those of the asymptomatic patients and controls （P 〈0.05）. The vector volume （VV） and vector symmetric index （VSI） in patients with soiling were significantly lower than those in preoperation and the controls （P 〈 0.05 ）. The VSI in the patients with constipation was significantly higher compared with the controls （ P 〈 0.05 ）. Conclusions The stooling function, colonic motility and anal sphincter performance manifest well in most of the patients after the transanal endorectal pull through operation for Hirschsprung＇s disease. Stooling disorders in few cases are probably related to decrease or disappearance of the sigmoid loops, dysfunction of the ＂ neorectosigmoid＂, an open and fixed anorectal angle and achalasia of the internal anal sphincter.