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促红细胞生成素与肾保护 被引量：1

The Protective Effect of Erythropoietin in Kidney
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摘要 促红细胞生成索（EPO）是一种多功能因子。肾是EPO分泌的主要器官，并有EPO受体表达。EPO与其受体结合后，通过抑制炎性反应，减少超氧损伤，减少细胞凋亡和坏死，促进再生，阻止肾的水通道和钠运载体下调，促进血管生成，减轻内皮损害、肾血管球硬化和小管间质性损伤而发挥肾保护作用。通过信号传导因子和转录激活因子、磷脂酰肌醇3激酶、核因子-kB、热休克蛋白等信号途径发挥其作用。目前对临床应用EPO的肾保护作用尚存争议。
作者 熊涛（综述） 董文斌（审校）
机构地区 四川泸州医学院附属医院新生儿科
出处 《国际儿科学杂志》 2007年第3期172-174,共3页 International Journal of Pediatrics
基金 四川省杰出青年学科带头人培养基金（04ZQ026-033）
关键词 促红细胞生成素 肾 信号传导
分类号 R692.5 [医药卫生—泌尿科学]
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参考文献25

  • 1Sharples EJ,Thiemermann C, Yaqoob MM. Novel applications of recombinant erythropoietin[J] .Curr Opin Pharmacol,2006,6(2): 184-189.
  • 2Baker JE.Erythropoietin mimics ischemic preconditioning[J].Vascu Pharmacol,2005,42(5-6) :233-241.
  • 3Eckardt KU,Kurtz.A.Regulation of erythropoietin production[J].Eur J Clin Invest,2005,35 (Suppl 3) : 13-19.
  • 4Plotkin MD, Goligorsky MS. Mesenchymal cells from adult kidney support angiogenesis and differentiate into multiple interstitial cell types including erythropoietin producing fibroblasts[J]. Am J Physiol Renal Physiol ,2006, 291 (4) :F902-912.
  • 5Rossent J,Eckardt KU.Erythropoietin receptors:their role beyond erythropoiesis [J]. Nephrol Dial Transplant,2005,20(6) : 1025-1028.
  • 6Sharples FA, Yaqoob MM.Erythropoietin in experiraental acute renal failure [J]. Nephron Exp Nephrol,2006,104(3) : e83-88.
  • 7Brines M,Cerami A.Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise[J]. Kidney Int,2006,70(2):246-250.
  • 8Patel NS,Sharples EJ, Cuzzocrea S,et al. Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo[J]. Kidney Int,2004,66(3) :983-989.
  • 9Erbayraktar S,Yilmaz O,Gokmen N,et al.ErythrOpoietin is a multifunctional tissue-protective cytokine[J].Curr Hematol Rep,2003,2(6):465-470.
  • 10Sharples EJ, Patel N, Brown P, et al. Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion[ J] .J Am Soc Nephrol,2004,15 (8) : 2115-2124.

同被引文献11

  • 1熊涛,董文斌,王明勇,邓存良,许开桂.促红细胞生成素减轻窒息新生儿血清诱导人肾小管细胞损伤[J].实用儿科临床杂志,2007,22(5):336-337. 被引量：11
  • 2胡语航,王兴勇.缺氧复氧肾损伤信号传导机制研究进展[J].儿科药学杂志,2007,13(3):58-60. 被引量：2
  • 3Ghezzi P, Brines M. Erythropoietin as an antiapoptotie, tissue- protective cytokine [ J]. Cell Death Differ,2004,11 (suppl 1 ) :37 -44.
  • 4Aggarwal A, Kumar P, Chowdhary G, et al. Evaluation of renal functions in asphyxiated newborns [ J 3. J Trop Pediatr ,2005 ,51 ( 5 ) : 295 - 299.
  • 5Zhang F, Wang S, Cao G, et al. Signal transducers and activators of transcription 5 contributes to erythropoietin - mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia[ J]. Neurobiol Dis ,2007,25 ( 1 ) :45 - 53.
  • 6Zhande R, Karsan A. Erythropoietin promotes survival of primary human endothelial cells through PI3 K - dependent, NF - kappaB - independent upregulation of Bcl - xL [ J ]. Am J Physiol Heart Circ Physiol, 2007,92 ( 5 ) : 2467 - 2474.
  • 7Okada T, Sawada T, Kubota K. Asialoerythropoietin has strong renoprotective effects against ischemia - reperfusion injury in a murine model [ J ]. Transplantation, 2007,84 ( 4 ) : 504 - 510.
  • 8Kim KH, Oudit GY, Backx PH. Erythropoietin protects against doxorubicin - induced cardiomyopathy via a phosphatidylinositol 3 - kinase - dependent pathway[J]. J Pharmacol Exp Ther,2008,24 ( 1 ) : 160 - 169.
  • 9Li J, Lang M J, Mao XB, et al. Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic/reperfused heart of rat [J]. Cardiovasc Drugs Ther ,2008 ,22 ( 4 ) :283 -291.
  • 10Yazihan N, Ataoglu H, Yener B, et al. Erythropoietin attenuates hydrogen peroxide - induced damage of hepatocytes [ J]. Turk J Gastroenterol,2007,8 (4) :239 - 244.

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国际儿科学杂志
2007年 第3期

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