期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脓毒症的诊治进展 被引量：2

Advances in Diagnosis and Treatment of Sepsis
原文传递
导出
摘要 脓毒症（sepsis）是一种发病率和病死率都很高的疾病。在美国，每年约有75万人发生脓毒症，其中约有21．5万人死亡（病死率高达28．7％），其病死人数几乎与因急性心肌梗死死亡的人数一样多。脓毒症发展到严重脓毒症以及脓毒性休克是一个连续的过程，在此过程中疾病的严重性逐步加深，病死率逐步升高。如果延迟识别、诊断和治疗，将会增加脓毒症的病死率，并消耗大量的医疗资源。所以早期识别和治疗严重脓毒症和脓毒性休克是非常重要的。
作者 曾其毅 杨文敏 曾华松
机构地区 广州儿童医院儿科
出处 《国际儿科学杂志》 2007年第3期232-234,共3页 International Journal of Pediatrics
关键词 严重脓毒症 脓毒性休克 诊治 急性心肌梗死 早期识别 病死率 医疗资源 发病率
分类号 R45 [医药卫生—治疗学]
  • 相关文献

参考文献27

  • 1Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis ff incidence, outcome, and associated costs of care[J]. Cri Care Med,2001,29(7) : 1303-1310.
  • 2Rice TW,Bemard GR.Therapeutic intervention and targets for sepsis[J]. Annu Rev Med,2005,56:225-248.
  • 3Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guiddines for the use of innovative therapies in sepsis[J] .Chest 1992, 101 (6) : 1644-1655.
  • 4Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/ SIS international sepsis definitions conference[J]. Crit Care Med,2003,34 (4): 1250-1256.
  • 5Goldstein B, Giroir B, Randolph A, et al. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics[J]. Pediatr Crit Care Med,2005,6(1 ) :2-8.
  • 6Tsiotou AG,Sakorafas GH,Anagnostopoulos G,et al.Septic shock;current pathogenetic concepts from a clinical perspective [ J ]. Med Sci Monit, 2005,11 (3) : RA76-85.
  • 7Marshall JC. Sepsis: current status, future prospects[J]. Curr Opin Grit Care, 2004,10(4) :250-264.
  • 8Bums JP. Septic shock in the pediatric patient: Pathogenesis and novel treatments[J]. Pediatr Emerg Care,2003,19(2) :112-115.
  • 9Spronk PE, Kanoore-Edul VS, Ince C. Microcirculatory and mitochondrial distress syndrome(MMDS) : a new look at sepsis//Pinsky MR, Payen D. Functional Hemodynamic Monitoring. 42th Berlin: Springer-Verlag, 2004: 47-69.
  • 10Ince C.The microcirculation is the motor of sepsis[J]. Grit Care,2005,9 (Suppl 4) : S13-19.

同被引文献44

  • 1祝益民.脓毒症相关监测指标的意义[J].中国小儿急救医学,2006,13(1):11-13. 被引量：15
  • 2Martin GS, Mannino DM, Eaton S, et al. The epidcmiology of sepsis in the United States from 1979 through 2000. N Engl Med,2003,348 (16) :1546-1554.
  • 3Wang H, Bloom O, Zhang M, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science, 1999,285 ( 5425 ) : 248 -251.
  • 4Merenmies J, Pihlaskari R, Laitinen J, et al. 30-kDa heparin-binding protein of brain(amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plas- ma membrane. J Biol Chem, 1991,266 (25) : 16722-16729.
  • 5Huttunen HJ, Fages C, Kuja-Panula J, et al. Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res, 2002, 62 (16) :4805-4811.
  • 6Gardella S, Andrei C,Ferrera D, et al. The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep,2002,3 (10) :995-1001.
  • 7Kokkola R,Sundberg E, Ulfgren AK,et al. High mobility group box chromosomal protein 1 :a novel proinflammatory mediator in synovi- tis. Arthritis Rheum,2002,46(10) :2598-2603.
  • 8Bell CW, Jiang W, Reich 3rd CF, et al. The extracellular release of HMGB1 during apoptotie cell death. Am J Physiol Cell Physiol, 2006.291 (6) : 1318-1325.
  • 9Calogero S,Grassi F, Aguzzi A, et al. The lack of chromosomal protein Hmgl does not disrupt cell growth but causes lethal hypogly- caemia in newborn mice. Nat Genet, 1999,22 (3) :276-280.
  • 10Tian J, Avalos AM, Mao SY, et al. Toll-like receptor 9-dependent activation by DNA containing immune complexes is mediated by HMGB1 and RAGE. Nat lmmunol,2007,8 (5) :487-496.

引证文献2

二级引证文献4

国际儿科学杂志
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部