骨桥蛋白OPN和黏附分子CD44v6在肺癌中的表达

Expression and clinicopathological significance of OPN and CD44v6 in lung cancer

背景与目的近年来关于细胞表面黏附分子(CD44)与肺癌关系的相关研究较多,而对骨桥蛋白(OPN)的研究还不太多。本研究旨在探讨OPN和CD44v6在肺癌中的表达水平及其相互关系。方法应用免疫组织化学方法对78例肺癌组织标本进行OPN和CD44v6检测。结果65例非小细胞肺癌中OPN和CD44v6阳性表达率分别为58.46%、66.15%,13例小细胞肺癌中OPN和CD44v6表达均为阴性(P<0.01)。OPN和CD44v6阳性表达率与患者TNM分期有密切关系(P<0.01),而与细胞分化程度无明显关系(P>0.05)。OPN和CD44v6在肺癌中的表达呈正相关(r=0.255,P<0.05)。结论OPN和CD44v6的表达同肺癌病理类型和分期有密切关系,二者在肺癌转移中可能起协同作用,有望作为临床评估非小细胞肺癌进展及预测肿瘤转移潜能的指标。

Background and objective There have been a lot of studies about surface adhesion molecule （CD44） in recent years, however study on osteopontin （OPN） is still few. The aim of this study is to investigate the levels of OPN and CD44v6 in lung cancer and their correlation. Methods OPN and CD44v6 expression were detected in 78 lung cancer tissues by immunohistochemistry. Results The positive rate of OPN and CD44v6 expression in non-small cell lung cancer （NSCLC） was 58.46% and 66.15% respectively, but no positive case in small cell lung cancer. The expression of OPN and CD44v6 in NSCLC was closely related to TNM stages （P〈0.01）, but not to cell differentiation （P〉0.05）. There was a remarkably positive correlation between the expression of OPN and CD44v6 （r= 0. 255, P〈0.05）. Conclusion The co-expression of OPN and CD44v6 may be involved in progression and metastasis of lung cancer. The interrelationship of OPN and CD44v6 was coordinative with development and metastasis of lung cancer. It might be helpful to predict the metastasis and prognosis of NSCLC.