摘要
目的Caco-2细胞模型特征及其在药物研究中的应用。方法概述了近年来Caco-2细胞模型在药物吸收机制、高通量筛选、药物相互作用、代谢及在药物剂型开发中应用情况。结果Caco-2细胞模型与整体吸收具有良好的相关性,可预测药物在体内的吸收、代谢规律。结论Caco-2细胞模型是药物体外研究的良好工具。
OBJECTIVE To introduce the characteristics of Caco-2 cell model and its development in drug researches. METHODS Caco-2 cell model is widely used in the researches on drug absorption mechanism,high throughput screening,interaction and metabolism. It is also applied in the study on pharmaceutics. RESULTS The caco-2 cell model has a good correlation to the data that was obtained in vivo. It can be used to predict the absorption and metabolism of drug in vivo. CONCLUSION Caco-2 cell model is an effective tool for the research of drug in vitro.
出处
《齐鲁药事》
2007年第5期293-295,共3页
qilu pharmaceutical affairs
