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Maspin在妇产科疾病中的研究进展 被引量：1

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摘要 Maspin（mammary—serpin）基因是1994年Zon等使用消减杂交（sub-tractive hybridization）的方法在对正常乳腺组织和乳腺癌组织进行比较时发现的．并且发现用该基因转染乳腺癌细胞系MDA2MB2435后，可降低癌细胞在裸鼠体内的成瘤能力，降低其穿透基底膜及转移的能力。有研究发现从大肠杆菌和昆虫细胞融合蛋白中提取纯化的两种重组maspin同样具有抑制肿瘤浸润的能力。目前的研究表明maspin基因是一种肿瘤抑制基因，在肿瘤的发生、进展中起到重要的作用，它具有调节细胞浸润、增加细胞的粘附力、降低细胞运动能力的作用．
作者 郭妮娅 薛敏
机构地区 中南大学湘雅三医院妇产科
出处 《现代医药卫生》 2007年第11期1651-1653,共3页 Journal of Modern Medicine & Health
关键词 妇产科疾病 MASPIN基因 乳腺癌细胞系 正常乳腺组织 成瘤能力 肿瘤抑制基因 基因转染
分类号 R735.102 [医药卫生—肿瘤]
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参考文献13

  • 1Mohsin SK,Zhang M,Clark M,et al.Maspin expression in invasive breast cancer:association with other prognostic factor[J].J Pathol,2003,199(4):432.
  • 2Sood AK,Fletcher MS,Gruman LM,et al.The paradoxical expression of maspin in ovarian carcioma[J].Clin Cancer Res,2002,8(9):2924.
  • 3Rose SL,Fitzgerald MP,White NO,et al.Epigenetic regulation of maspin expression in human ovarian carcinoma cells[J].Gynecol Oncol,2006.102(27):319.
  • 4Abd EI-Wahed MM.Expression and subcellular location of maspin in human ovarian epi-thelal neoplasms:correlation with clinicopathologic features[J].J Egypt Natl Canc Inst.2005,17(3):173.
  • 5Chengen Xu.M Ruhul Quddus,C James Sung.et al.Maspin expression in CIN 3,micro-invasive squamous cell carcinoma,and invasive squamous cell carcinoma of the uterine cervix[J].Modern Pathology,2005,18:1102.
  • 6Murai S,Maesawa C,Masuda J,et al.Abrerrant maspin expression in human endometrial cancer[J].Cancer Sci,2006,97(9):883.
  • 7Li HW,Leung SW,Cheung AN.et al.Expression of maspin in gestational trophoblastic disease[J].Gynecol Oncol,2006,101(1):76.
  • 8Chin SS,Tong YK,Chiu RW.Detection of the placental epigenetic signature of the maspin gene in maternal plasma[J].Proc Natl Acad Sci USA,2005,102(41):14753.
  • 9Maass N,Hojo T,Rosel F.et al.Hepsin and maspin are inversely expresssed in laser capture microdissectioned prostate cancer[J].J Urol,2003,169(4):1316.
  • 10Solomon LA,Munkarah AR,Schimp WL,et al.Maspin expression and localization impact on angiogenesis and progrosis in ovarian cancer[J ].Gynecol Oncol,2006,101 (3):385.

同被引文献8

  • 1Chim SSC. Detection of the lacental epigenetic signature of the maspin gene in maternal plasma [ J ]. Proc Natl Acad Sci USA, 2005,102 : 14753-14758.
  • 2丰有吉,沈铿.妇产科学(八年制版)[M].北京:人民卫生出版社,2006:77-78.
  • 3Lo YMD, Tein MS. Quantitative analysis of fetal DNA in maternal plasma and serum : implication for noninvasive prenatal diagnosls[J]. Am J Hum Genet, 1998,62:768-775.
  • 4Dennis LYM. Fetal DNA in maternal plasma: progress through epigenetics[ J]. Ann N Y Acad Sci, :2006, 1075: 74-80.
  • 5Licchesi JDF, Herman JG. Methylation-Specific PCR[ J]. Methods Mol Biol,2009,507:305-323.
  • 6IIIlanes S, Pana M, Serra R, et al. Increased tree Ietal DNA levels in the plasma of pregnant women in early pregnancy are observed in patients who subsequently develop preeclampsia and intrauterine growth restriction [ J ]. Prenat Diagn, 2009, 29 ( 12 ) : 1118-1122.
  • 7lshihara N, Matsuo H, Murakoshi H, et al. Increased apoptosis in syncytiotrophoblasts in human term placentas complicated by either PET or IUGR[ J]. Am J Obstet Gynecol, 2002, 186 : 158- 166.
  • 8Hahn S, Chitty LS. Non-invasive prenatal diagnosis: implications for antenalal diagnosis and the management of high-risk pregnancies [ J ]. Semin Feta Neonatal Med, 2008, 13:55-56.

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现代医药卫生
2007年 第11期

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