复方血竭贴膏对子宫内膜异位症大鼠血浆PGF2α及血清IL-1β的干预作用

The Effect of ProstaglandinF_(2a) (PGF_(2a)) in the Blood Plasma and Interleukin-1β(IL-1β) in the Blood Serum of Endometriosis in the Rats Treated with Complex Prescription Dragon’s Blood Plaster

[目的]研究复方血竭贴膏的制备工艺,评价该制剂穴位敷贴对子宫内膜异位症模型大鼠的治疗效果,并进一步探讨可能的作用机理。[方法]①制剂制备:以血竭为主药经过稠膏制备、挥发油提取、浸膏制备制成血竭贴膏;②动物实验:采用了自体子宫内膜移植,建立子宫内膜异位症模型,设立对照,观察各组大鼠血浆PGF2α及血清IL-1β水平,[结果]复方血竭贴膏具有抑制异位内膜生长、能够降低大鼠血浆中PGF2α水平,对IL-1β水平的影响不明显。[结论]复方血竭贴膏穴位敷贴能够抑制异位内膜生长、促进腺体萎缩,从而达到治疗子宫内膜异位症作用。

[Objective] To optimize the exact preparative technique of complex prescription Dragon＇s Blood Plaster（DBP）, to evaluate the therapeutic effect to endometriosis rats with acupoint therapy and to discuss its probable mechanism. [Methods] Making into DBP through the preparation of ultra fine powder,extraction of the volatile oils and their ointments were made as well. Induced by surgery for the experimental endometriosis ,observed that the levels of PGF2α in the blood plasma and IL-1β in the blood serum in different control groups. [Results] Complex prescription DBP could inhibit the ectopic endometrium hyperplasic , and decrease the levels of PGF2α. No significant difference in IL-1β in the blood serum. [Conclusion]The treatment by acupoint therapy with complex prescription DBP is effective to endometriosis. It could inhibit the ectopic endometrium hyperplasic and promote the shrinking of glands.