摘要
CD4+ 助手 T (TH ) 房间在免疫反应起关键作用。最近 TH 房间，称为的 TH (IL-17 ) ， TH17 或煽动性的 TH (THi ) 的一个新奇子集，作为织物的批评调停人被识别了发炎。这些房间生产 IL-17 (也叫的 IL-17A ) andIL-17F，分享类似的规定的二很相应的 cytokines。这里，我们报导在 293T 房间， IL-17 和 IL-17F 的 whenoverexpressed 形成不仅 homodimers 而且 heterodimers，我们作为 IL-17A/F 说出它。充分区分的老鼠 THi 房间自然地也也分泌 IL-17A/F asIL-17 和 IL-17F 人二聚的 cytokines。在作为与人相比导致 IL-6 和 KC (CXCL1 ) 的力量的重组体 IL-17A/F 蛋白质展览中介层次二聚的 cytokines。IL-6 和 KC 表示的 IL-17A/F 规定依赖于 IL-17RA 和 TRAF6。因此， IL-17A/F cytokine 代表 T 房间调整煽动性的回答并且可以为治疗各种各样的调停免疫者的疾病用作一个新奇目标的另一机制。
CD4＋ helper T （TH） cells play crucial roles in immune responses. Recently a novel subset of TH cells, termed THIL-17, TH 17 or inflammatory TH （THi）, has been identified as critical mediators of tissue inflammation. These cells produce IL-17 （also called IL-17A） and IL-17F, two most homologous cytokines sharing similar regulations. Here we report that when overexpressed in 293T cells, IL-17 and IL-17F form not only homodimers but also heterodimers, which we name as IL-17A/F. Fully differentiated mouse THi cells also naturally secrete IL-17A/F as well as IL-17 and IL-17F homodimeric cytokines. Recombinant IL-17A/F protein exhibits intermediate levels of potency in inducing IL-6 and KC （CXCL 1） as compared to homodimeric cytokines. IL-17A/F regulation of IL-6 and KC expression is dependent on IL-17RA and TRAF6. Thus, IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatory responses and may serve as a novel target for treating various immune-mediated diseases.
