造血干细胞移植治疗系统性红斑狼疮1例报告并文献复习

To Treat Patient with Sytemic Lupus Erythematosus by Autologous Marrow Stem Cell Transplantation:A Case Report and Literature Review

目的探讨自体骨髓干细胞移植(ABMSCT)对系统性红斑狼疮(SLE)的疗效。方法患者为SLE迁延不愈并伴有自身免疫性溶血性贫血(AIHA),采集自体骨髓造血干细胞,预处理用环磷酰胺(CTX)2.4 g静滴连用2天,依托泊苷(VP-16)0.4 g/m2d1,0.5 g/m2d2(即依据病人体表面积第1天用0.4 g/m2,第2天用0.5 g/m2),预处理后回输自体骨髓悬液。用惠尔血(rhG-CSF)刺激粒细胞的恢复,观察ABMSCT前后临床表现和免疫学指标的变化。结果ABM-SCT后患者的临床症状明显缓解,血象各指标恢复正常。结论ABMSCT对SLE有较好的疗效,远期疗效还需长期随访。

Objective To investigate therapeutic effect of autologous bone marrow stem cell transplantation （ABMSCT） on sytemic lupus erythematosus （SLE）, Methods One patient with refractory SLE and AIHA was chosen, Transplantation of haematopoietic stem cell^＋ acquired by autologous marrow aspiration was adopted. BM stem cell was reinfused after by cyclophosphamide （ CTX）2.4 g for two days andVP-16 0, 4g/m^2 for the first day and 0.5 g/m^2 for the second day. Granulocyte recovery was stimulated by G-CSF, Both clinical manifestations and immunologic markers were compared before and after transplantation. Results The patient had clinical remission after transplantation, and the targets of blood routine examination became normal, Conclusion The therapy of autologous ABMSCT for SLE is remarkably effective, It is required to follow-up for evaluation long effect.