大剂量静脉人免疫球蛋白联合激素治疗慢性格林-巴利综合症效果分析

Curative Effects of High-dose Intravenous Immunoglobulins Combining with Steroids for Chronic Inflammatory Demyelinating Polyneruropathoes

目的研究大剂量静脉用人血免疫球蛋白（IVIg）联合类固醇激素与单独应用类固醇激素对慢性炎症性脱髓鞘性多发性神经病（chronic inflammatory demyelinating polyneruropathoes,CIDP）的治疗效果对比。方法CIDP患者共32例,应用IVIg联合糖皮质激素治疗15例设为实验组,年龄17-67岁;仅用糖皮质激素治疗17例,年龄21-69岁,设为对照组。治疗前和治疗后分别测定患者的肌力（Fugl-Meyer运动积分）、日常生活能力（Barthel指数）。结果治疗前后Fugl-Meyer运动积分和Barthel指数的对比发现实验组与对照组比较差异有统计学意义（P〈0.01）,肌力恢复和日常生活能力恢复程度明显增加。结论IVIg联合激素治疗CIDP的效果比单独用激素治疗效果要好,且越早越好。

Objective To evaluate the curative effect difference between high-dose intravenous immunoglobulins （IVIg） combining with steroids and steroids only for chronic inflammatory demyelinating polyneruropathoes （CIDP）. Methods Thirty two cases with CIDP were randomly divided into two groups ： treatment group （ n = 15 ） was treated with high-dose intravenous immunoglobulins combined with steroids, control group （n = 17 ） with steroids only. The muscle force （Fugl-Meyer scale） and daily live ability （ Barthel index） were mensurated before and after the treatment. Results The curative effect of high-dose intravenous immunoglobulins combined with steroids was better than steroids only for CIDP. Conclusions Results suggest that the effect that high-dose intravenous immunoglobulins associate with steroids treat CIDP was better than steroids only.