女性类风湿关节炎患者血清中性激素水平的分析

Analysis of Serum Sex Hormones in Female Patients with Rheumatoid Arthritis

目的探讨性激素与类风湿关节炎(Rheumatoid Arthritis,RA)发病的关系。方法放射免疫分析法检测30例绝经后女性RA患者血清中雌二醇、睾酮及孕酮水平,以29例健康女性为对照组。结果女性RA患者血清中雌二醇、睾酮及孕酮水平与对照组相比差异无统计学意义,但RA组血清中雌二醇/睾酮和雌二醇/孕酮比值明显高于对照组(P<0.05)。结论女性RA患者存在着雌二醇/睾酮、雌二醇/孕酮比值升高的现象,提示性激素比例失衡可能是导致易感人群中RA发病的一个因素。

Objective To study the relation between sex hormones level and rheumatoid arthritis （RA）：Methods Estradiol, testosterone and progesterone of 30 postmenopausal female RA patients and 29 controls were determined by radioimmunoassay. Results Serum level of estradiol,testosterones and progesterone in postmenopausal female RA patients had no significant differences as compared to the controls. The ratios of estradiol/testosterones and estradiol/progesterone of RA patients were significantly higher than that of controls （P 〈 0.05 ）. Conclusions Elevated ratios of estradiol to testosterones and estradiol to progesterone in female RA patients suggest that an imbalance of sex hormones are related to the pathogenesis of RA.