1,6二磷酸果糖联合纳洛酮治疗新生儿缺氧缺血性脑病的疗效研究

The clinical effects of FDP combined with Naloxone for HIBD in neonates

目的:评价1,6二磷酸果糖联合纳洛酮治疗新生儿缺氧缺血性脑病的疗效及安全性。方法:采用病例对照研究,将92例新生儿缺氧缺血性脑病患者,随机分为1,6二磷酸果糖联合纳洛酮治疗组与常规治疗对照组,观察两组临床疗效,14d后CT检查情况,出院时新生儿行为神经测定,进行统计学分析。结果:治疗组临床总有效率91.67%,明显优于对照组65.90%(P<0.05),CT检查正常率和出院时NBNA评分明显高于对照组(P<0.05)。结论:在常规治疗新生儿缺氧缺血性脑病的基础上加用1,6二磷酸果糖及纳洛酮可明显提高疗效,对降低病死率、致残率有一定的临床价值,无明显的副作用,是一种有效、安全、可供选择的治疗方法。

Obiective ： To evaluate the efficacy and security of FDP combined with Naloxone on HIBD. Methods： 92 cases of HIBD were randomly allocated to treatment group,which was treated by FDP combined with Naloxone and control group, which was treated by conventional therapy. After 14 days, therapeutic effect were evaluated by measuring scale of NBNA and the normal rate of CT examination. Results：Comparing with the control group, the grades of NBNA and the normal rate of CT examination in the treatment group had statistical significance （P〈 0.05）. The effective rate in the treatment group was 91.67%, distinctly higher as compared with 65.90% in the control group. Conclusion ;FDP combined with Naloxone is safe and effective in treating neonates with HIBD, and can improve the case-fatality rate and the mutilation rate without conspicuous side effect.