5471例GNU患者泌尿生殖道衣原体支原体检测及耐药性研究

Antibiotic susceptivity of mycoplasma and chlamydia separated from 5471 GNU patients′ urethra and genitalia

目的:探讨衣原体(CT),解脲支原体(UU)和人型支原体(MH)在性病门诊患者中感染情况及支原体的耐药情况。方法:采用英国UNIPATH公司生产的Clean View衣原体快速免疫测定试剂盒和中山市天洋电子生物传感器有限公司生产的支原体培养鉴定药敏试剂盒,对5 471例非淋菌性尿道炎(GNU)患者分泌物进行检测。结果:5 471例GNU患者,检出单纯UU阳性1 938例,占35.43%,单纯MH阳性24例,占0.44%,UU+MH阳性204例,占3.73%,单纯CT阳性402例,占7.35%,UU、CT总检出率分别是43.84%、11.59%。女性感染率显著高于男性(P<0.01);UU、MH、UU+MH对克拉霉素、交沙霉素、强力霉素、美满霉素较为敏感。结论:泌尿生殖道支原体感染主要以UU为主,CT、UU、MH、UU+MH、UU+CT的耐药率存在一定差异。药物治疗支原体感染以克拉霉素、交沙霉素最好,其次是强力霉素、美满霉素。

Objective： To examine the antibiotic susceptivity and infection ratio of CT, UU and MH for the STD patients. Methods：The clean view chlamydia fast asaay reagent made by U. K. UNIPATH corp and mycoplasma culture and antibiotic susceptivity reagent made by Zhongshan Tian Yang electronic biosensor carp were used to examine the secretion of the GNU patients＇urethra and genitalia. Results： 1 938 （35.43 % ） GNU patients were detected only UU;24 （0. 44% ） patients were detected only MH;204（3.73% ） patients were detected both UU and MH;402（7. 35% ） patients were detected only CT. Total detection ratio of UU and CT is respectively 43.84 and 11.59%. Infection rate of female patiens was distinctly high than male （ P 〈 0. 01 ）. UU, MH, UU ＋ MH were susceptive to Clarithromycin, Josamycin, Doxycycline and Minocycline. Conclusion： UU is the major pathogeny for genitalia and urethra infection. CT, UU, MH and UU ＋ MH have different antibiotic susceptivities. Clarithromycin and Josamycin are best therapy remedy, and the second selection are Doxycycline and Minocycline.