乳腺良性病变和乳腺癌临床病理特征及相关性分析

Clinical pathological features and relativity of breast benign diseases and breast cancer

目的:探讨乳腺良性病变和乳腺癌的临床病理特征及相互关系。方法:对2222例乳腺良性病变和乳腺癌的临床病理资料进行回顾性分析,免疫组化检测ER在癌旁组织中的表达。结果:乳腺增生性病变占乳腺良性病变的94.8%,乳腺浸润性癌在恶性肿瘤中占95.8%;乳腺癌平均发病年龄为47.1岁,显著高于乳腺增生性病变的34.98岁(Wilcoxon秩和检验,P<0.0001);有恶性肿瘤家族史的乳腺疾病患者,发生乳腺癌的概率(6.5%)大于发生乳腺良性病变的概率(1.9%),P<0.001;72%的乳腺增生性病变存在>3种病理成分;乳腺癌旁组织中不典型增生的发生率(23.5%)显著高于良性乳腺增生性病变中不典型增生的发生率(2.49%),P<0.01;乳腺癌旁不同良性病变与癌一样,对ER均有高表达。结论:乳腺增生性病变是女性最常见的病变成分复杂的良性疾病,其演变过程与乳腺癌有关。

OBJECTIVE： analyze the clinical pathological features and relativity of breast benign diseases and breast cancer. METHODS： The clinical pathological data of 2 222 cases of breast benign diseases and breast cancer were analysed retrospectively, and the ER expression in breast cancer＇s adjacent tissue was examined. RESULTS： A total of 94.8% of all breast benign diseases were proliferative breast diseases; 95.8% of all malignant cases were infiltrating cancer. The average age （47. 1） of breast cancer was higher than that （34. 9） of proliferative breast diseases, P〈0. 000 1. The breast cancer risk for the patients with malignant family history was higher than that for those without mahgnant family history, P〈0. 001. Seventy two per cent of proliferative breast diseases appeared simuhaneously more than three pathological dements. The incidence rate of AH in breast cancer adjacent tissue （23. 5% ）was much higher than that in pure proliferative breast lesion process（2.49%）, P〈0. 01. ER appeared high expres sion in breast cancer and various lesions of breast cancer adjacent tissue. CONCLUSION： Proliferative breast disease is the most common breast benign disease with multi-lessions, and its process is related to breast cancer.