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小泛素相关修饰物与神经系统变性疾病

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摘要 近二十年来,有关泛素的研究得到了飞速的发展,泛素化是细胞体内一种非常重要的蛋白质翻译后修饰方式,泛素一蛋白酶体途径(ubiquitin—proteasome system,UPS)是指泛素通过标记靶蛋白使其被蛋白酶体识别、降解,在细胞凋亡、DNA修复及细胞分裂等生理和病理过程中发挥着重要作用。小泛素相关修饰物(small ubiquitin—related modifier,SUMO)是新发现的泛素类蛋白家族的重要成员之一,
出处 《中华神经科杂志》 CAS CSCD 北大核心 2007年第5期347-349,共3页 Chinese Journal of Neurology
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