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腺苷酸激活蛋白激酶的营养调控机制研究进展 被引量：1

Advances in Regulating Mechanism of AMPK on Nutrient
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摘要 腺苷酸激活蛋白激酶(AMP-activated protein kinase,AMPK)能感知细胞能量代谢状态的改变,并可通过影响细胞物质代谢的许多环节来维持细胞的能量平衡。在试验研究中的种种迹象表明,应激因子造成AMPK的活化与动物营养代谢病之间存在一定的关联。为此,作者总结了AMPK的营养调控功能和其他生理调节作用,以便为AMPK在营养调控和应激调控的研究提供坚实的理论基础。 It has been confirmed that AMPK can perceive the change of metabolism state of cell and maintain the cell energy equilibrium through some ways. At the same time, many researches have indicated the existence of the relevance between the activation of AMPK by stress factors and the nutritional metabolic disease. Thus, this review provides the solid theory foundation for research of nutrient regulation and stress regulation through narrating its nutrient regulating functions and other physiological regulating characters.
作者 毕晋明 张敏红 王永军
机构地区 中国农业科学院北京畜牧兽医研究所 西北农林科技大学动物科技学院
出处 《中国畜牧兽医》 CAS 2007年第5期14-17,共4页 China Animal Husbandry & Veterinary Medicine
关键词 腺苷酸激活蛋白激酶 能量代谢 转录 营养调控 AMP-activated protein kinase energy metabolism transcription nutrition regulation
分类号 Q493 [生物学—生理学]
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参考文献18

  • 1Andersson U，Filipsson K，Abbott C R，et al．AMP—activated protein kinase plays a role in the control of food in take[J]．J Biol Chem，2004，279(13)：12005～12008．
  • 2Chen H C，Bandyopadhyay G，Sajan M P，et al．Activation of the ERK pathway and atypical protein kinase C isoforms in exercise—and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport[J]．J Biol Chem，2002，277：23542～23562．
  • 3Chen Z P，Stephens T J，Murthy S，et al．Effect of exercise intensity on skeletal muscle AMPK signaling in humans[J]．Diabetes，2003，52：2205～2212．
  • 4Garcia—Gil M，Pesi R，Perna S，et al．5-aminoimidazole-4-car-boxamide riboside induces apoptosis in human neuro—blastoma cells[J]．Neuroscience，2003，117(4)：811～820．
  • 5Halse R，Fryer L G D，McCormack J G．Regulation of glycogen synthase by gluc—ose and glycogen：a possible role for AMP2 activated protein kinase[J]．Diabetes，2003，52(1)：9．
  • 6Holmes B，Dohm G L．Regulation of GLUT4 gene expression during exercise．Med Sci Sports Exerc，2004，36：1202～1206．
  • 7Hudson E R，Pan D A，James J，et al．A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrbythmias[J]．Curr Biol，2003，13(10)：861～866．
  • 8Kefas B A，Cai Y，Ling Z，et al．AMP—activated protein kinase can induce apoptosis of insulin—producing MIN6 cells through stimulation of c-Jun—N—terminal kinase[J]．J Mol Endocrinol，2003，30(2)：151～161．
  • 9Light P E，Wallace C H，Dyck J R，et al．Constitutively active adenosine monophosphate—activated protein kinase regulates voltage—gated sodium channels in ventricular myocytes[J]．Circulation，2003，107(15)：1962～1965．
  • 10Minyoung L，Jin—Taek H，Hye-Jeong L，et al．AMP—activated Protein Kinase Activity Is Critical for Hypoxia—inducible Factor1 Transcriptional Activity and Its Target Gene Expression under Hypoxic Conditions in DU145 Cells[J]．J Biol Chem，2003，278(41)：39653～39661．

同被引文献10

  • 1Hanks S K. , Quinn A M. Protein kinase catalytic do- main sequence database : identification of conserved features of primary structure and classification of fami- ly members[J]. Methods Enzymol, 1991,200 : 38-62.
  • 2Fryer L G, Carling D. AMP-activated protein kinase and the metabolic syndrome[J]. Biochem Soc Trans, 2005,33: 362 - 366.
  • 3Proszkowiec W M, Richards M P, Ramachandran R, et al. Characterization of the AMP-activated protein ki- nase pathway in chickens [J]. Comp Biochem Physiol B Bioehem MolBio1,2006,143(1) :92-106.
  • 4Carling,D. The AMP-activated protein kinase cascade-a unifying system for energy control [J]. Trends Bio- chem. Sci, 2004,29 : 18-24.
  • 5McFadden J W, A Cot B. Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells [J]. Biochem Biophysi Res Commun, 2009,390 (3) : 388-393.
  • 6Yang W,Ying Z h. Effects of acute bouts of swimming exercise on AMPKα2 expression in mouse skeletal muscle. [J]. J Exerc Sci Fit,2010,8(1): 11-16.
  • 7Philp L K,Muhlhausler B S,Janovska A,et al. Mater- nal overnutrition suppresses the phosphorylation of 5'-AMP-activated protein kinase in liver, but not skeletal muscle, in the fetal and neonatal sheep[J]. Physiol Regulatory Integrative Comp Physiol, 2008, 295:1982-1990.
  • 8Viollet B,Andreelli F,Jorgensen S B,et al. The AMP- activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity[J]. Clin Invest, 2003, 111:91-98.
  • 9Ian SALT,Jakub W. C,Simon A. H,et al. AMP-acti- vated protein kinase : greater AMP dependence,and preferential nuclear localization, of complexes contai- ning the α2 isoform[J]. Biochem J, 1998, 334: 177- 187.
  • 10陈代文,张克英.AMPK对动物营养代谢的调节作用[J].动物营养学报,2002,14(3):1-6. 被引量：13

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中国畜牧兽医
2007年 第5期

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