脑神经联结异常—自闭症认知神经科学研究新进展

Abnormal Neural Connectivity—New Direction of Neurocognitive Research for Autism

本文在回顾自闭症行为研究、认知研究的基础上,介绍和分析了当前认知神经科学领域有关自闭症的有代表性的研究成果:脑神经联结异常假设及其相关证据。脑神经联结异常假设的主要观点是:自闭症个体同时并存脑神经“局部联结过度”和“长距联结不足”的现象。自闭症个体脑生理结构研究和脑功能研究的相关发现均对此观点分别予以了支持。脑神经联结异常假设的提出对于整合现有自闭症领域多层面的研究成果、深入认识自闭症、及早发现和干预自闭症提供了极为有价值的方向。

Based on the review of behavioral and cognitive studies in autism, the article introduced and anal- ysed the most recent and representative findings of the disorder in cognitive - neuroscience ： evidence for abnormal neural connectivity. According to the abnormal neural connectivity hypothesis, autism co - occurred with ＂local over- connectivity＂ and ＂distant under- connectivity＂. Structural and functional brain connectivity studies in autism did provide some support for the hypothesis. The abnormal neural connectivity hypothesis provided some directions in integrating the multi - dimensional research findings, understanding the disorder, early diagnosis and intervention.