潜伏期间苯三酚宫颈注射促产程进展49例临床观察

Clinical observation of the progress of labor accelerated by cervical injection of phloroglucinol during latent phase

目的：探讨间苯三酚在潜伏期对解除宫颈痉挛、消除宫颈水肿和加速宫口扩张的作用。方法：将初产妇、产程处于潜伏期内宫口开大2～3cm伴宫颈水肿者100例，随机分为间苯三酚组49例，阿托品组51例，观察两组产妇的产程变化和围产结局。结果：间苯三酚组宫口扩张平均速度及用药至宫口开全的时间较阿托品组有显著性差异（P〈0．01），两组分娩方式比较有显著性差异（P〈0．05），间苯三酚组用药后2h的宫颈水肿消失率较阿托品组无显著性差异（P〉0．05）。结论：潜伏期宫颈局部注射间苯三酚可消除宫颈水肿，加速宫口扩张，缩短产程，降低难产发生率。

Objective： To explore the effects of cervical injection of phloroglucinol on relieving from cervical spasm, cervical edema and on dilatation of cervix. Methods： One hundred primiparea with cervical edema were randomly divided into phloroglucinol therapy group （ n = 49 } and atropine therapy group （ n = 51 } when their cervix dilated 2 - 3 cm in the course of labor during latent phase. The change of course of labor and perinatal outcome were observed. Results ： There was significant difference in the comparison of average velocity of dilatation of cervix and the time from administration of drug to full dilatation of cervix between phloroglucinol therapy group and atropine therapy group （ P 〈 0.01 ）, and significant difference was also found in the comparison of delivery modes between the two groups （ P 〈 0. 05）. But there was no significant difference in the comparison of ratio of disappearance of cervical edema after administration of drug for 2 hours between the two groups （ P 〉 0. 05 }. Conclusion： Injecting phloroglucinol locally can eliminate cervical edema, accelerate dilatation of cervix, shorten the course of labor and reduce the incidence of dystocia during latent phase.