PTEN和P53在宫颈鳞癌中的表达

Expression of PTEN and P53 in Squamous Carcinoma of Cervix and Its Relationship with Occurrence and Development

目的探讨宫颈鳞癌组织中PTEN和P53蛋白表达及其与宫颈癌发生发展的关系。方法采用免疫组化(SP)法检测50例宫颈鳞癌组织及30例癌旁不典型增生组织,50例正常宫颈组织PTEN和P53的表达。结果50例宫颈鳞癌组织中20例PTEN阳性表达占40%(20/50),31例呈P53阳性表达占62%(31/50);30例宫颈非典型增生组织中,21例呈PTEN阳性表达占70%(21/30),10例呈P53阳性表达占30%(10/30)。50例正常宫颈组织中,PTEN和P53阳性表达率分别为100%(50/50)和0%(0/50);PTEN阳性表达与宫颈癌的发生发展呈负相关(P<0.05),P53阳性表达与宫颈癌的发生发展呈正相关(P<0.05)。结论PTEN和P53可能在宫颈癌的发生、发展中起重要作用。PTEN和P53检测为进一步阐明宫颈癌的发生、发展机制及寻找有效地抑制宫颈癌的演进途径提供了理论基础。

Objective To explore carcinoma of the cervix and its relationships ma of the cervix. Methods To detect the the expressions of PTEN and P53 protein in the squamous with occurrence and development of the squamous carcinoexpressions of PTEN and P53 protein in the 50 cases of squamous cell carcinoma of cervix,30 cases of atypical hyperplasia tissues of tumor - adjacent and 50 cases of normal mucosa of uterine cervix by immunohistochemistry SP method. Results The positive rates of expressions of PTEN and P53 were 40% （20/50） ,62% （31/50）respectively in the 50 cases of the squamous carcinoma of the cervix;the positive rates of expressions of PTEN and P53 were 70% （21/30） and 30% （9/30）respectively in the 30 cases of atypical hyperplasia tissues of tumor- adjacent ; the positive rates of expressions of PTEN and P53 werel00% （50/50） and 0% （ 0/50 ） ; the posi- tive expressions of PTEN had negative correlations with the occurrence, development of the squamous carcinoma of the cervix（ P 〈0. 05）,the positive expressions of P53 had positive correlations with the occurrence,development of the squamous carcinoma of the cervix （ P 〈 0. 05 ）. Conclusion PTEN and P53 maybe plays the important roles during the process of occurrence and development of the squamous carcinoma of the cervix. The detections of PTEN and P53 protein explore furtherly the mechanisms of occurrence,development of uterine cervix carcinoma and provide rationale for early diagnosis and early treatment of uterine cervix cancer.