30例神经梅毒的临床特征

Clinical features of 30 cases of neurosyphilis

目的分析神经梅毒的临床特征。方法回顾分析我院30例神经梅毒患者的年龄、性别、临床表现、脑脊液改变和神经影像学检查等资料。结果30例患者符合神经梅毒的诊断。最常见的临床类型为脑膜血管型梅毒占37%,其次为脊髓痨占20%、麻痹性痴呆占20%。平均发病年龄是50.8岁,除了1例为女性外,均为男性。常见的症状是脑卒中,占37%,常见的体征是腱反射减弱、痴呆和深感觉障碍,分别占30%。结论神经梅毒的临床表现复杂多样,临床上应高度警惕。

Objective To assess the clinical features of neurosyphilis （NS）. Methods A retrospective study was performed on the age, gender, clinical manifestations, changes in cerebrospinal fluid, and neuroimaging findings of 30 patients diagnosed as NS in our hospital Results The most common clinical type was meningovascular syphilis （ 37% ）, followed by tabes dorsalis （ 20% ） and general paresis （ 20% ）. Patients were all males except one female, with a mean onset age of 50.8 years. The most common symptom was stroke （ 37% ）, and the most frequent signs included tendon hyporeflexia （ 30% ）, dementia （ 30% ）, abnormalities in deep sensation （ 30% ）. Conclusions Neurosyphilis has diverse clinical presentations, and clinicians should pay much attention to it.