盐酸氮[艹卓]斯汀及其在皮肤科的应用

Azelastine hydrochloride and its application in dermatology

盐酸氮[艹卓]斯汀为长效抗过敏药物，选择性作用于H1受体，具有抗组胺、稳定肥大细胞及抗炎三方面的作用，且不良反应小。该药在皮肤科的应用越来越广泛，尤其用于瘙痒性皮肤病，包括荨麻疹、特应性皮炎、湿疹和皮肤搔痒症等疾病的治疗。应注意同时使用中枢神经系统抑制药物、西咪替丁和酮康唑等药物对其有影响。

Azelastine hydrochloride, a long-acting antiallergic drug and selective histamine HI-receptor antagonist, has the effects of antihistamine, stabilizing mast cell membrane and anti-inflammation. Its application in dermatology has been increasingly expanded, especially in the treatment of itching skin diseases, such as urticaria, atopical dermatitis, eczema, pruritus, etc. Attention should be paid to the interaction of it with central nerve system inhibitory drugs, cimetidine, ketoconazole, and so on.