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白血病细胞内重现性基因突变

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摘要 白血病细胞内基因突变对白血病的发生发展起着十分重要的作用。近年来，随着白血病发病“双重打击”学说的提出，对白血病细胞内基因突变的研究报道日益增多。主要的重现性基因突变有RUNX1、FLT3、CEBPA、PTPN11、SHIP、RAS、KIT、NPM1和NOTCH1等；其中CEBPA、NPM1和NOTCH1突变的患者预后较好，而RUNX1、FLT3、PTPN11和RAS突变的患者预后较差；SHIP和KIT等突变的预后意义尚不明确。
作者 任金海（综述） 罗建民（审校）
机构地区 河北医科大学第二医院血液科
出处 《国际输血及血液学杂志》 CAS 2007年第3期231-234,共4页 International Journal of Blood Transfusion and Hematology
关键词 白血病细胞 基因突变
分类号 R734.2 [医药卫生—肿瘤]
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参考文献29

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国际输血及血液学杂志
2007年 第3期

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