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白血病干细胞起源、分子机制及其临床意义 被引量：1

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摘要 干细胞样白血病细胞或白血病干细胞具有无限增殖潜能，维持着白血病细胞的生长和进展。研究表明正常造血干细胞或定向分化前体细胞可因Bcl-2家族功能获得性突变、Bmil基因突变、Wnt信号通路失调和／或Notch受体异常活化而转化为白血病干细胞。对白血病干细胞发生机制的深入系统研究有助于进一步阐明白血病发生的分子机制，并具有潜在的临床治疗意义。
作者 代红胜（综述） 郑以州（审校）
机构地区 中国医学科学院中国协和医科大学血液学研究所实验血液学国家重点实验室
出处 《国际输血及血液学杂志》 CAS 2007年第3期235-238,共4页 International Journal of Blood Transfusion and Hematology
关键词 白血病 白血病干细胞
分类号 R733.71 [医药卫生—肿瘤]
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参考文献28

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同被引文献7

  • 1马军.急性髓细胞白血病的分子靶向治疗进展[J].中国实用内科杂志,2005,25(8):679-680. 被引量：5
  • 2原现华,林凤茹,姚尔固.白细胞介素-3受体研究进展[J].临床荟萃,2006,21(19):1443-1444. 被引量：2
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  • 6Minami Y,Yamamoto K,Kiyoi H,et al.Different antiapoptotic pathways between wild-type and mutated FLT3:insights into therapeutic targets in leukemia.Blood,2003,102(8):2969.
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国际输血及血液学杂志
2007年 第3期

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