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NPM1基因突变与急性髓细胞白血病

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摘要 NPM1（Nucleophosmin，又称B23、Numatrin或N038）是一种主要的核仁磷酸化蛋白，其定位于核仁的颗粒区，具有重要的肿瘤抑制作用。近一年来的研究发现NPM1基因第12号外显子的突变是急性髓细胞白血病（AML），尤其是正常核型AML中最常见的一种分子遗传学异常，且与其发病密切相关。对NPM1基因突变的深入研究在AML患者的疗效预测、预后判断及靶向治疗中有着重要的临床意义。
作者 颜灵芝（综述） 陈苏宁（审校） 吴德沛（审校）
机构地区 江苏省血液研究所苏州大学附属第一医院血液科
出处 《国际输血及血液学杂志》 CAS 2007年第3期246-249,共4页 International Journal of Blood Transfusion and Hematology
关键词 NPM1基因 突变 急性髓细胞白血病
分类号 R733.71 [医药卫生—肿瘤]
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参考文献21

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国际输血及血液学杂志
2007年 第3期

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