西地那非对高原人体运动血气的影响

Effect of Sildenafil on Blood Gas in Human Body after Exercise at High Alititude

目的:探讨西地那非对高原人体运动血气的影响。方法:在海拔3700m选择10名已习服半年的男性士兵,在海拔5380m选择10名已习服2个月的男性士兵,均采用服药前(对照组)后(实验组)的自身对比运动负荷双盲实验。运动结束检测pH、PCO2、PO2、HCO3-、AaDO2及SaO2的含量。结果:海拔3700m和5380m负荷运动,实验组较对照组pH、PaO2、HCO3、、SaO2增高,差别有显著性(P<0.01或0.05),PaCO2、AaDO2降低,差别非常有显著性(P<0.01)。结论:西地那非可提高高原人体作业效率,增强氧合功能,适合人体在高原特殊情况下的应急抗低氧用药。

Objective. To study the effect of sildenafil on blood gas indexes in human body after exercise at high altitude. Methods： 20 male soldiers were selected from 3 700m and 5 380m altitudes each 10 for a double blind self control trial. Level of pH,PCO2 ,PO2, HCO3^- ,AaDO2 and SaO2 were detected after exercise before and after sildenafil administration. Results： Compared with the control group, the contents of pH,PaO2, HCO3^-,SaO2 were significantly higher （P〈0. 01 or 0. 05） and PaCO2 ,AaDO2 were decreased （P〈0. 01） at sildenafil group both at 3 700m and 5 380m after load exercise. Conclusions： Sildenafil can increase exercise capability and oxygenation ability at high altitude, which is an anti--hypoxia drug for emergency at high altitude.