西宁地区中老年男性血尿酸与冠状动脉病变的关系

The Relationship Between Serum Uric Acid and Coronary Artery Disease in Middle and Old-aged Male in Xining

目的:探讨西宁地区中老年男性血尿酸与冠状动脉病变的关系。方法:入选行冠状动脉造影住院男性病例290例,检测血脂、血糖、血压、血尿酸等。根据血尿酸水平分为两组:正常尿酸组与高尿酸血症组,再根据是否合并糖尿病、高血压分为4个亚组,比较各组间冠脉病变支数、病变总积分及心血管危险因素聚集性。结果:高尿酸血症组较正常尿酸组在肥胖、嗜酒、吸烟、高血压、高血糖、高甘油三酯血症、低高密度脂蛋白血症的发生率上明显偏高(P<0.05),高尿酸血症组2支血管病变、3支血管病变发生率及Gensini积分明显高于正常血尿酸组(P<0.05);同样高尿酸血症合并糖尿病或高血压等时冠脉单支病变、2支病变、3支病变的发生率及Gensini积分均显著高于正常尿酸合并糖尿病或高血压组(P<0.05)。结论:高尿酸血症患者合并更多的心血管危险因素,冠脉病变更严重且弥漫,并与糖尿病、高血压等有协同作用。

Objective： To evaluate the correlation between serum uric acid and coronary artery disease in middle--aged and old--aged male patients in Xining. Methods： 290 male patients underwent coronary angiograpHy were selected, the levels of serum uric acid, blood pressure, blood sugar, triglyceride（TG）, total cholesterin （TC）, low density lipoprotein cholesterin （LDL--C）, high density lipoprotein cholesterin （HDL--C） were measured. All patients were divided into two groups according to the level of uric acid： normal UA group and hyperuricemia group. Whether have the hypertension or type 2 diabetes mellitus （T2DM）, we divided each group into four subgroups and compare the number of ill vessels, Gensini cumulative index and cardiovascular risk factors. Results： The incidences of fat, drinking, smoking, hypertension, high blood sugar, TG and low HDL--C in hyperuricemia group are much higher than those in normal UA group（P〈0. 05）. That vessel disease occurred in two and triple branch and Gensini cumulative index in hyperuricemia group were much higher than those in normal UA group （P〈0. 05）, The occurrence of single, two and triple vessel disease and Gensini cumulative index in hyperuricemia with T2DM or hyper- tension group were much higher than those in normal UA with T2DM or hypertension group （P〈0.05）. Conclusions： The patients with hyperuricemia have more cardiovascular risk factors, and have multi--vessel disease or diffuse coronary lesions. Hyperuricemia always associates with T2DM and hypertension.