奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗晚期大肠癌的临床观察

Clinical study of oxaliplatin in combination with leucovorin and 5-fluorouracil for advanced colorectal cancer

目的评价奥沙利铂联合亚叶酸钙和大剂量氟尿嘧啶（5-FU）持续48 h静脉滴注治疗晚期大肠癌的疗效和安全性。方法32例大肠癌患者采用静脉滴注奥沙利铂100 mg/m^2,亚叶酸钙200 mg/m^2,亚叶酸钙滴注之后用5-FU 0．5 g静注,接着用5-FU 3．0 g/m^2持续静脉滴注48h,每2周1次,2次为1个周期。结果32例病例中,平均疗程数为4个周期,其中完全缓解（CR）1例,部分缓解（PR）15例,稳定（SD）12例,进展（PD）4例,总有效率（CR＋PR）为50%。不良反应为恶心、呕吐和骨髓抑制,但多为Ⅰ～Ⅱ度,一过性感觉异常。结论奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗晚期大肠癌疗效较高,不良反应轻而且安全,患者容易耐受,值得推广使用。

Objective To evaluate the clinical efficacy and safety of oxaliplatin in combination with Leucovorin and 5-fluorouracil continuous infusion 48 hours for patients with advanced colorectal cancer. Methods 32 cases used drip-injecting oxaliplatin 100mg/m^2. Leucovorin 200mg/m^2 and after dripping leucovorin, 5-FU 0.5g into vein followed by dripping 5-FU 3.0g/m^2 into vein lasting 48 hours were performed that were repeated per two weeks. Every four weeks was a cycle. Results 31 patients were experienced 4 periods of treatment averagely. It showed that CR 1 ,PR 15,SD 12,PD 4 cases. The overall effective rate（CR ＋ PR） was 50%-The main side effects were mile neuro-sensory toxicity,suppression of bone marrow,nause and vomiting of grade Ⅰto Ⅱ . Conclusion Oxaliplafin in combination with leucovorin and 5-fluorouracit is a high response regimen for advanced colorectal cancer with mile toxicity which can be practiced safely. It is deserved to be spreaded and applicated.