绵羊铅镉联合中毒的研究

Studies on Lead cadmium Poisoning in Sheep

研究了白银矿区周围绵羊以消瘦和贫血为主要特征的疾病。通过检测食物链系统及绵羊全血、被毛和组织器官中１３种矿物元素（Ｐｂ、Ｃｄ、Ｚｎ、Ｆｅ、Ｍｎ、Ｍｏ、Ｃｕ、Ｆ、Ａｓ、Ｓｅ、Ａｌ、Ｃａ、Ｐ）的含量，分析血液生理生化指标的变化，揭示出现地牧草中Ｐｂ、Ｃｄ的含量高，分别为（１１１．２±９８．４）μｇ／ｇ和（１２．０±１．２）μｇ／ｇ；动物体内的Ｐｂ、Ｃｄ沉积量亦极显著高于允许值（Ｐ＜０．０１）；动物呈低色素小细胞性贫血，血清ＬＤＨ、ＡＬＴ活性和Ｔ３含量显著升高（Ｐ＜０．０１），血清蛋白含量降低（Ｐ＜０．０１），以及实质器官变性、坏死，肾小管上皮细胞核包涵体等病理学特点。

A disease characterized by emaciation and anaemia in sheep from surroun ding of the Baiyin mining area was described.The contents of thirteen minerals in the soils,for ages and in the blood,hair and tissues of animals were measured.The concentrations of lead and cadmium in forages were(111.2±98.4)and(12.0±1.2)μg/g,respectively.Compared with healthy sheep,the contents of lead and cadmium in blood,hair and tissues of affected sheep were significantly higher;the serum LDH and ALT activities and T 3 content were significantly higher;the serum protein concentrations were lower( P <0.01).The anemia occurred in the affected sheep belongs to a hypochromic and microcytic pattern.Pathological changes were characterized by the degeneration and necrosis inparenchymatous organs and the intranuclear inclusion in renal tubular epithelial cells.It is suggested that the disease of sheep in this region might be a lead cadmium poisoning,originated mainly from an environmental pollution.