黄芪对老年带状疱疹患者Th1/Th2失衡调节作用的探讨

Study on the modulatory Effect of Astragalus Membranaceus on the imbalance Thl/Th2 in elder Patients with Herpes Zoster

目的探讨黄芪对带状疱疹患者血清Th1/Th2细胞因子水平的影响。方法选择60例带状疱疹患者随机分为黄芪治疗组和病毒唑治疗组各30例,治疗前后分别用双抗体夹心法酶联免疫吸附实验(ELISA)监测外周血淋巴细胞介素——2(IL—2)、白细胞介素—4(IL—4)、白细胞介素—10(IL—10)、r—干扰素(r—IFN)水平;并以同样方法检测20例体检正常健康者为对照组。结果带状疱疹患者组血清中IL—4、IL—10水平较缝康对照组显著增高(P<0.01);IL—2、r—IFN水平较健康对照组显著降低(P<0.01)。黄芪治疗组患者治疗后,IL—4、IL—10水平显著降低(P<0.01),而IL—2、r—IFN水平显著增高(P<0.01)。病毒唑治疗组治疗前后上述指标无明显改变(P>0.05)。结论黄芪能调节带状疱疹患者体内Th1/ Th2细胞因子的失衡,改善患者机体免疫功能紊乱状态,对促进病情的好转具有重要意义。

Objective：To explore the influence of Astragalus Membranaceus（AM） on serum cytokines, Th1 ,including interleukin-2（IL-2） and r-interferon（r-IFN）,and Th2,including interleukin- 4（IL-4） and interleukin- 10（IL- 10）,in patients with Herpes Zoster（HZ）h. Methods： sixty HZ patients were randomly derided into the AM treated group and the ribavirin treated group .Levels of serum IL-2,IL-4,IL10 and r-IFN of the patients and 20 healthy person,selected from donors for control group.were determined by sandwich enzymelinked immunosorbent assay（ELISA）technique. Results：Levels of serum IL-4 and IL-10 in HZ patients were significantly higher and those of IL-2 and r-IFN were significantly lower than those in the healthy control（all P〈0.01）.These parameters were significantly improved in the patients of the AM group after treatment,but with no change in the patients of the ribavirin group. Conclusion：AM can modulate the imbalance state of Th1/ Th2 in Herpes Zoster patients,improve their immune function disturbance,that shows important significance in treating HZ.