酒精性滑脉模型的建立及其心血管生理学基础研究

Method of Setting up Slippery Pulse Mode Caused by Alcohol and Its Cardiovascular Physiological Mechanism

目的:探讨酒精性滑脉模型的建立方法、实用性及其形成的心血管生理学基础。方法:①令受试者饮用61度白酒100ml左右,经中医师诊脉确认为滑脉后,分别采用NX-6型脉动信息采集系统及Magnetom Avanto 1.5T超导磁共振成像仪进行桡动脉压力波记录及心脏、桡动脉(寸口处)扫描,观察其桡动脉脉搏波、桡动脉形态及心功能改变。②家兔用浓度为40%酒精8ml/kg灌胃,经中医师诊脉确认为滑脉后,采用NX-3型脉动信息采集系统记录其颈动脉压力波。结果:与脉滑变前相比:①人酒精性滑脉模型受试者的搏出量、心输出量、心指数、射血分数及左心室流出道流速增大;舒张末期及收缩末期左心室容积减小;外周血管扩张,轴心位移幅度增大;桡动脉脉搏波符合典型滑脉波形特征。②家兔酒精性滑脉模型:颈动脉压力脉搏波变化规律与人酒精性滑脉模型者桡动脉脉搏波完全一致。结论:适量使用酒精时,其扩血管和强心作用符合中医理论关于滑脉形成原理的论述,造模效果好,实用性强。

Objective： To study the method of setting up, practicability and the cardiovascular physiological mechanism of slippery pulse model caused by alcohol. Methods： ①Scanned the heart and radial artery （cunkou） by the Magnetom Avanto 1.5T and record the pressure wave of radial artery by NX-6 Pulse Diagnosis Equipment after the subjects had gotten 100ml of distillate spirit of 61 degree and defined as the slippery pulse. ②Record the pressure wave of carotid artery of rabbits defined as the slippery pulse after intragastric administration of distillate spirit of 40 degree 8ml per kilogram by NX-3 Pulse Diagnosis Equipment. Results： ①Slippery pulse model of human subjects： the stroke volume （SV）, cardiac output （CO）, cardiac index （CI）, ejection fraction （EF） and the peak velocity of the blood flow increased; the end-diastole volume （EDV） and end-systole （ESV） decreased; the periph blood vessel distended and the amplitude of the offset of the axis stepped up; the characteristics of the pulse wave of cunkou were consistent with the characteristics of typical slippery pulse wave. ② The characteristics of the pulse wave of slippery pulse model of rabbits were coincident with that of human subjects. Conclusion： The method of setting up slippery pulse model with alcohol is consistent with the mechanism of slippery pulse in the theory of traditional Chinese medicine and is practicable.