肝郁型黄褐斑小鼠模型的建立及其与现有模型的比较研究

Establishment of Chloasma Mouse Model with Syndrome of Liver-qi Stagnation and Comparative Study of It with Existent Models

目的:建立并验证肝郁型黄褐斑小鼠模型,并与现有其他模型进行比较。方法:注射黄体酮同时,进行慢性束缚和紫外线局部照射。结果:黄体酮+紫外线+束缚复合法造模较其他方法更能导致皮肤丙二醛(MDA)升高和超氧化物歧化酶(SOD)降低以及皮肤黑色素细胞的增加,并且具有肝郁证的行动学表现。结论:黄体酮+紫外线+束缚法建立的肝郁型黄褐斑小鼠多因素模型获得成功。

Objective： To establish and authenticate the chloasma mouse model with syndrome of liver-qi stagnation, and compare it with other existent models. Method： After the injection of progesterone, chronically constrained them and gave them partially ultraviolet radiation. Results： Multiple models of progesterone injection and ultraviolet radiation compounding with chronic constraint can heighten MDA, depress SOD, and increase melanocytes of skin. Meanwhile, the ethology of this model showed it＇s syndrome of liver-qi stagnation. Conclusion： The multiple factor chloasma mouse model of liver-qi stagnation syndrome has been built successfully.