血管紧张素转化酶基因多态性在终末期肾功能衰竭患者中的分布及其意义

Angiotensin converting enzyme gene polymorphism in patients with end stage renal failure

目的 为了进一步阐明由于血管紧张素(ACE)基因多态性而导致的循环中ACE水平不同在肾脏疾病进展中的意义。方法 对77例终末期肾功能衰竭(ESRF)患者和150名正常人ACE基因多态性进行了分析。结果 ACE基因缺失型(DD)(15.6％VS.6.0％,P<0.01)和插入型(DI)(53.2％VS39.3％,P<0.05)在ESRF患者中的发生频率明显高于正常人,而Ⅱ型的发生频率则明显低于正常人(31.2％VS54.7％,P<0.01)。结论 ACE基因多态性与肾脏疾病病情进展及肾小球硬化的发生有一定联系。ACE基因多态性的分析,有可能成为判断肾脏疾病患者预后的一个标记物。

Objective To evaluate the role of angiotensin-converting enzyme (ACE) gene polymorphism in the progression of renal diseases. Methods ACE gene polymorphism was analyzed in 77 patients with end stage renal failure (ESRF) and 150 normal control. Results The frequences of DD and DI genotype were significantly higher in ESRF patients than normal control (DD, 15.6% VS 6.0%, P<0. 01, DI: 53. 2% VS 39.3%, P<0. 05), while the frequency of II genotype was much lower in ESRF compared with normal controls (31. 2% VS 54. 7% , P< 0. 01). Conclusion The DD and DI genotype of ACE gene are associated with the development of renal failure and may be a risk marker for progression of renal diseases.