婴幼儿期甲状腺功能对少年期智力水平的影响

EFFECT OF THYROID FUNCTION DURING INFANCY ON SUB INTELLIGENCE IN THE JUVENILE

1979年在贵州省麻江县河坝乡(地克病患病率3.1％)对0～2岁的婴幼儿35人及1980～1982年每年出生的0～1岁婴儿54人,共89人,测T_4、TSH和摄X线片,甲状腺功能低下(甲低)38人,甲状腺功能正常(甲正)51人。1992年进行追踪观察,追踪到69人(77.5％),全部作临床精神神经检查,部分作智力测验、TSH测定及X线片骨龄判断。结果显示“婴幼儿期甲低组的低智检出率(55.1％)明显高于甲正组(22.9％)(P<0.01),甲低指标1项异常组的中度低智检出率明显低于2项及2项以上以上异常组(P<0.05),说明婴幼儿期甲状腺功能对少年期智力水平有明显影响。

In iodine deficient region we have performed serum Tt, TSH determination and Roentgenological examination of skull and wrist on 35 infants borne before the iodized salt prophylaxis and 54 borne each year in 1980-1982, after prophylaxis in 1979-1982. In accordance with thyroid function 89 infants were divided into two groups: 38 being hypothyroidism group,51 euthyroidism group. Ten years ago these infants grew into the juveniles, a follow up study was carried out on 69 out of 89 juveniles (77. 5%) by means of intelligence test, Roentgenological examination of wrist and serum TSH detection. The results showed that the percentage of mental subnormality in hypothyroidism group (56%) was higher than that in euthyroidism group(23%);6 cases with moderate mental subnormality were found from the numbers with two or more indexes of hypothyrodism in hypothyroidism group. This suggested that the subintelligence of juvenile is concerned in their thyroid function during infancy,obviously.