角膜Kayser-Fleischer环41例临床观察

A Clinical Survey on 41 Cases with Cornea K-F Rings

目的通过对肝豆状核变性患者中发现的角膜 Kayser-Fleischer(K-F)环的临床观察,认识 K-F环对该病早期诊断的价值。方法运用裂隙灯显微镜对41例角膜 K-F 环的形态、部位、色泽,以不同照明法和放大倍数进行观察,并用眼科多用尺进行环的测量。结果 41例角膜 K-F 环患者中病程2年以内者为Ⅰ级8例(19.51%),2年以上者分别为Ⅱ级19例(46.34%)和Ⅲ级者14例(34.15%);脑型和混合型均发现 K-F 环;内脏型有69.2%发现 K-F 环。说明41例角膜 K-F 环患者中病程、临床分型与相关生物学指标具有一定的相关性。结论角膜 K-F 环是肝豆状核变性患者的特征性体征,发生率很高,对诊断肝豆状核变性具有重要价值。(中国眼耳鼻喉科杂志,2007,7:172-173)

Purpose To explore the clinical features of the cornea K-F rings of the patients with hepatolenticular degeneration and to elucidate its early diagnostic value. Methods The shape, location and color of cornea K-F rings of 41 cases with hepatolenticular degeneration were examined with a slit lamp at different magnification times and illuminations and the width of the cornea K-F ring was measured with a ophthalmological multi-ruler. Results Of the 41 cases, there were 8 class Ⅰ cases（ 19.51% ） whose courses of disease lasted within 2 years, 19 class Ⅱ（46.34% ） and 14 class Ⅲ cases whose courses were more than 2 years;The cornea K-F rings were identified in all the patients with mixed and cerebullar pattern, in 13 cases（69.2% ） with splanchnic pattern. The cornea K-F rings of patients in hepatolenticular degeneration are related with their course of disease and clinical classification and correlated to some biological parameters. Conclusion Cornea K-F ring is one of the characteristic signs of the patients with hepatolenticular degeneration. It is of important value in diagnosis of hepatolenticular degeneration.