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microRNA表达谱与消化器官肿瘤的发生、诊断及治疗 被引量：4

MicroRNA profiles and initiation,diagnosis and treatment of cancers in digestive organs
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摘要 microRNA (miRNA)是一种大小约21-23个碱基的、非蛋白编码单链小分子RNA,下调参与许多重要细胞活动(包括发育、增殖、分化、凋亡)基因的表达.近期的研究发现,miRNA在肿瘤的发生和发展中起着重要的作用,miRNA具有癌基因和抑癌基因的作用.已发现若干miRNA直接参与消化器官(包括肝、结肠、胰腺、胃、胆管)肿瘤的发生和发展,miRNA表达谱与消化器官肿瘤的诊断、病理分级、临床分期、疾病进展、预后和对治疗的反应性等相关.miRNA表达谱可以鉴定能抑制下游活化的癌基因信号途径或作用于与肿瘤发生和发展有关的蛋白编码基因的miRNA靶基因,miRNA介导的治疗还可能用于肿瘤的预防和治疗. MicroRNA （miRNA） is a kind of small non-coding RNA containin 21 to 23 nucleotides in length that down-regulates gene expression during various crucial cell processes such as development, proliferation, differentiation and apoptosis. Recent studies supported an important role of miRNA in the initiation and progression of human malignancies. Some miRNAs may function as oncogenes or tumor suppressors. It is found that several miRNAs are directly involved in human cancers of digestive organs, including liver, colon, stomach, pancreas and bile duct. In addition, miRNA expression profiling of tumors in digestive organs has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment, Profiling has also been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or target protein coding genes involved in cancer. Moveover, miRNA-mediated therapy may be a powerful tool for cancer prevention and therapy.
作者 李欣 李小青 黄士昂
机构地区 华中科技大学同济医学院附属协和医院干细胞中心/湖北省生物靶向治疗重点实验室
出处 《世界华人消化杂志》 CAS 北大核心 2007年第11期1241-1245,共5页 World Chinese Journal of Digestology
基金 国家杰出青年基金 No.30225038~~
关键词 MICRORNA 表达谱 肿瘤 消化器官 MicroRNA Expression profile Tumor Digestive organ
分类号 R735 [医药卫生—肿瘤]
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同被引文献38

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世界华人消化杂志
2007年 第11期

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