与乙型肝炎病毒感染相关的易感或拮抗基因的研究进展

Advance in genetic factors influencing hepatitis B virus infection

乙型肝炎病毒(HBV)感染是世界范围的严重公共卫生问题之一.HBV感染后,机体对病毒的清除能力以及疾病的进展和不同临床转归,除了与病毒因素和环境因素有关外,在很大程度上取决于个体间基因组的差异.本文就近年来与乙型肝炎病毒感染相关的易感或拮抗基因的研究进展及研究中存在的问题作一综述,主要包括影响机体免疫应答的基因、人类白细胞抗原(HLA)、肿瘤坏死因子(TNF)、白细胞介素(IL)、干扰素(IFN)等,同时对这一领域的研究前景作一展望.

Hepatitis B virus （HBV） infection is a major global health problem. A complex combination of environment and virus, especially host genetic factors, play a critical role in determining both susceptibility to HBV persistence and different clinical outcomes after HBV infection. In this review, we summarized the main relevant genes such as human leukocyte antigen （HLA）, tumor necrosis factor （TNF）, interleukins （ILs）, interferons （IFNs）, etc. However, in order to identify all the relevant polymorphisms that affect the outcome of HBV infection, alternative strategies such as genome-wide association studies with large sample sizes are required to define the majority of the related genes.