广州市1701例狂犬疫苗免疫者流行病学及免疫效果分析

Immunological Analysis of 1701 Persons Vaccinated with Rabies Vaccine in Guangzhou City

目的了解2003年广州市疾病预防控制中心门诊部接诊的狂犬病疫苗免疫者的流行病特征及抗体产生情况,为我市狂犬病监测提供部分信息和依据。方法对广州市疾病预防控制中心门诊部2003年狂犬病接种者的登记资料进行统计分析,采用ELISA法对2003年在我门诊注射狂犬疫苗1701例人群进行抗体检测。结果不同年龄组人群的抗体阳性率在89.66%～98.41%,低年龄组人群的抗体阳性率高于高年龄组人群。结论注射狂犬疫苗的人群抗体阳性率仍未能达到100%,对结果阴性者应及时补种疫苗。

Objective To evaluate the serological status of individuals receiving rabies vaccine at the outpatient department of Guangzbou City Center for Diseases Control and Prevention in 2003. Method Information from 1701 individuals receiving rabies vaccine was obtained from the outpatient department, and the data were analyzed using statistical methods. ELISA method was used to test for the antibody production. Result The rate of seroconversion in various subpopulations of these 1701 vaccinated individuals was in the range of 89.66%-98.41%. The percentage of seroeonvemion in younger age groups was higher than the elderly. Conclusion The percentage of seroconversion was less than 100%. A booster dose is required for those seronegative individuals.