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糖皮质激素治疗鼻息肉的病理生理学机制

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摘要 目前关于糖皮质激素(glucocorticoids,GC)治疗鼻息肉的确切机制还不是很明确,鼻息肉、哮喘和过敏性鼻炎有着共同的特征,例如黏膜嗜酸性粒细胞和肥大细胞的浸润,局部产生IgE。最近的研究发现,应用GC治疗后鼻息肉组织中白细胞数量减少有几种机制:
作者 刘冰 吴建
出处 《实用医学杂志》 CAS 2007年第10期1591-1593,共3页 The Journal of Practical Medicine
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  • 1Mygind N,Dahl R,Bachert C.Nasal polyposis,eosinophil dominated inflammation and allergy[J].Thorax,2000,55(2):79-83.
  • 2Pawankar R.Nasal polyposis:an update:editorial review[J].Curr Opin Allergy Clin Immunol,2003,3 (1):1-6.
  • 3Bachert C,Gevaert P,Holtappels G,et al.Total and specific IgE in nasal polyps is related to local eosinophilic inflammation[J].J Allergy Clin Immunol,2001,107(4):607-614.
  • 4Hamilos D L,Thawley S E,Kramper M A,et al.Effect of intranasal fluticasone on cellular infiltration,endothelial adhesion molecule expression,and proinflammatory cytokine mRNA in nasal polyp disease[J].J Allergy Clin Immunol,1999,103(1 Pt 1):79-87.
  • 5Pelaia G,Vatrella A,Cuda G,et al.Molecular mechanisms of corticosteroid actions in chronic inflammatory airway diseases[J].Life Sci,2003,72 (14):1549-1561.
  • 6Benson M,Strannegard I L,Strannegard O,et al.Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines,eosinophils,eosinophil cationic protein,and IgE but has no significant effect on IFN-gamma,IL-lbeta,TNF-alpha,or neutrophils[J].J Allergy Clin Immunol,2000,106(2):307-312.
  • 7Benson M,Olsson M,Rudemo M,et al.Pros and cons of microarray technology in allergy research[J].Clin Exp Allergy,2004,34(7):1001-1006.
  • 8Meagher L C,Cousin J M,Seckl J R,et al.Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes[J].J Immunol,1996,156(11):4422-4428.
  • 9Leung D Y,Hamid Q,Vottero A,et al.Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta[J].J Exp Med,1997,186(9):1567-1574.
  • 10Hamilos D L,Leung D Y,Muro S,et al.GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone[J].J Allergy Clin Immunol,2001,108(1):59-68.

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